Modulation of Vascular Endothelial Growth Factor Angiogenic Activity by ADP-Ribosylation
Angiogenesis is a complex series of interdependent events which basically involves Chemotaxis, proteolytic digestion of extracellular matrix, cell proliferation, vascular tube formation, anastomoses with other vascular sprouts, and cell-cell, and cell-matrix adhesion. Studies on angiogenesis have revealed that these processes are regulated by a balance of positive and negative inducers of which cytokines and growth factors are the primary stimulators (1–3). Research over the last few years have indicated the pivotal role of vascular endothelial growth factor (VEGF) in the regulation of normal and abnormal angiogenesis (3). Because of the specificity of VEGF for endothelial cell migration, proliferation and tube formation, VEGF is considered to be a major stimulus for wound angiogenesis.
KeywordsVascular Endothelial Growth Factor Cholera Toxin Endothelial Cell Migration Angiogenic Activity Broad Response
Unable to display preview. Download preview PDF.
- 4.Leibovich S.J. Presented at 1997 Gordon Conf on Angiogenesis. Google Scholar