Angiogenesis — Critical Assessment of in-Vitro Assays and in — Vivo Models
Angiogenesis or neovascularization is a complex in-vivo phenomenon. Originally postulated more than 50 years ago by Michaelson, the growth of new blood vessels (either from stem cells during embryogenesis or from pre-existing mature vessels during wound healing processes) is most probably stimulated by released chemical factors1. Michaelson alluded to the existence of an x-factor of neovascularization and studied its expression in experimental models and clinical conditions1,2. Attempts to isolate the Michaelson x-factor have led to the discovery of a myriad of “angiogenic factors”3–6.
KeywordsVascular Endothelial Cell Angiogenic Factor Wound Healing Process Mitogenic Activity Corneal Angiogenesis
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