Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in Autoimmune Liver Disease
ANCA were detected in 67% of sera from patients with primary sclerosing cholangitis (n=15), in 83% of sera from patients with auto-immune chronic active hepatitis (n=18) and in 35% of sera from patients with primary biliary cirrhosis (n=20). ANCA were not detected in non-autoimmune chronic liver diseases. Characterization studies of the antigens involved showed that ANCA in autimmune liver disease are not directed against myeloperoxidase (mpo), proteinase 3 (pr3) or elastase (hle), but that ANCA in autoimmune liver disease show reactivity with lactoferrin, a 67/66 kD protein combination or a 63/54 kD protein combination on Western Blots.
KeywordsPrimary Biliary Cirrhosis Primary Sclerosing Cholangitis Antineutrophil Cytoplasmic Antibody Primary Biliary Cirrhosis Patient Crescentic Glomerulonephritis
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