P-ANCA as a Diagnostic Marker in Ulcerative Colitis

  • Kai Deusch
  • Katrin Oberstadt
  • Werna Schaedel
  • Manfred Weber
  • Meinhard Classen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


P-ANCA that do not react with myeloperoxidase (MPO) have been claimed to serve as a useful diagnostic marker in the differential diagnosis of inflammmatory bowel disease (IBD). Therefore, in this study we determined the frequency of MPOnegative-p-ANCA in patients with inflammatory bowel disease and correlated the presence with intestinal and extra-intestinal disease manifestation. In 44 out of 65 (68%) sera from patients with ulcerative colitis (UC) but in only 14 of 66 (21%) with Crohn’s disease (CD) MPO-negative-p-ANCA were detected whereby colonic involvement and extraintestinal manifestations seemed to be important. There was no correlation to therapy, activity, sex, age, extent and duration of disease. Moreover, the sera did not exhibit significant reactivity in ELISAs testing for Cathepsin G-, Lactoferrin-, Myeloperoxidase-, Elastase- or Proteinase 3- specificity.


Inflammatory Bowel Disease Ulcerative Colitis Primary Sclerosing Cholangitis Sclerosing Cholangitis Antineutrophil Cytoplasmic Antibody 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Kai Deusch
    • 1
  • Katrin Oberstadt
    • 1
  • Werna Schaedel
    • 2
  • Manfred Weber
    • 1
  • Meinhard Classen
    • 1
  1. 1.II.Department of MedicineTechnical University MunichGermany
  2. 2.Medical Clinic IVUniversity Erlangen-NürnbergGermany

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