Antineutrophil Cytoplasmic Auto-Antibodies in Sera from Patients with Ulcerative Colitis after Proctocolectomy with Ileo-Anal Anastomosis

  • Dominique Reumaux
  • Jean-Frédéric Colombel
  • Bernard Duclos
  • Stanislas Chaussade
  • Jacques Belaïche
  • Serge Jacquot
  • Jean-Louis Dupas
  • Christine Molis
  • Patrick Duthilleul
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Presence of antineutrophil cytoplasmic auto-antibodies (ANCA) in ulcerative colitis could be an epiphenomenon related to colonic inflammation and/or may reflect a primitive disturbance of immune regulation. In this regard, study of ANCA status after the whole colorectal mucosa has been removed could favor one of these two hypothesis. We compared the prevalence of ANCA in a first group of 70 patients with non operated UC and in a second group of 32 patients with UC having had a proctocolectomy with ileoanal anastomosis. Perinuclear ANCA (p-ANCA) were found in 34/70 (49%) of the first group as compared to 11/32 (34%) in the second group (NS). Our results further support that the presence of ANCA in UC reflects an immune disturbance not linked to the presence of the target organ.

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Colonic Inflammation Ileoanal Anastomosis Colorectal Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Saxon, A., Shanahan, F., Landers, C., Ganz, T., Targan, S., 1990, A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease, J Allergy Clin Immunol. 86: 202 - 10PubMedCrossRefGoogle Scholar
  2. Duerr, R.H., Targan, S., Landers, C.J., Sutherland, R., Shanahan, F., 1991, Neutrophil autoantibodies in ulcerative colitis: comparison with other colitides/diarrheal diseases, Gastroenterology 100: 1590 - 6PubMedGoogle Scholar
  3. 3.
    Colombel, J.F., Reumaux, D., Duthilleul, P., Noèl, L.H., Gower-Rousseau, C., Paris, J.C., Cortot, A., 1992, Antineutrophil cytoplasmic auto-antibodies in inflammatory bowel disease, Gastroenterol Clin Biol in pressGoogle Scholar
  4. Truelove, S.C., Witts, L.J., 1955, Cortisone in ulcerative colitis. Final report on atherapeutic trial, BrJ Med. 2: 1041 - 8CrossRefGoogle Scholar
  5. Wiik, A., 1989, Delineation of a standard procedure for indirect immunofluorescence detection of ANCA, APMIS97 (Suppl I ): 12 - 13Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Dominique Reumaux
    • 1
  • Jean-Frédéric Colombel
    • 2
  • Bernard Duclos
    • 2
  • Stanislas Chaussade
    • 2
  • Jacques Belaïche
    • 2
  • Serge Jacquot
    • 2
  • Jean-Louis Dupas
    • 2
  • Christine Molis
    • 2
  • Patrick Duthilleul
    • 1
  1. 1.Service d’Hémato-ImmunologieCentre HospitalierValenciennes CédexFrance
  2. 2.Groupe d’Etudes des Affections Inflammatoires du Tube Digestif (GETAID)France

Personalised recommendations