Summary
Treatment and outcome of 111 patients who fell ill with Wegener’s granulomatosis (WG) between 1966 and 1990 were analysed retrospectively. Two regimens of treatment were distinguished: “conventional” treatment, i.e. daily application of cyclophosphamide/corticosteroids (FAUCI scheme) or azathioprine/ corticosteroids or corticosteroids alone, and “stage-adapted” treatment, characterized by change of different treatments (e.g. cyclophosphamide pulse therapy, cotrimoxazole) according to the extent and activity of disease. In patients who received stage-adapted treatment, exacerbations occurred significantly more frequent than in conventionally treated patients, while lethal outcome was much more frequent in conventionally treated patients.
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© 1993 Springer Science+Business Media New York
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Briedigkeit, L., Ulmer, M., Göbel, U., Natusch, R., Reinhold-Keller, E., Gross, W.L. (1993). Treatment of Wegener’s Granulomatosis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_89
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DOI: https://doi.org/10.1007/978-1-4757-9182-2_89
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