Indentification of Apparent Dual ANCA Specificities in a Subset of Patients with Systemic Vasculitis and Crescentic Glomerulonephritis

  • Phataraporn Teeraratkul
  • John A. Thorson
  • John D. Kemp
  • James A. Goeken
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

23% of a random selection of ANCA (+) patients had dual, non-cross reactive autoantibody specificities. We found no clinical difference in such patients as compared to those having a single antibody. A second group of ANCA (+) patients had neither anti-MPO nor anti-PR3 autoantibody specificity. These findings suggest that multiple, coincident ANCA specificities occur more commonly than previously reported, and that additional, unidentified ANCA specificities are present in some patients.

Keywords

Ulcerative Colitis Primary Sclerosing Cholangitis Crescentic Glomerulonephritis Autoantibody Specificity Alkaline Phosphatase Substrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cohen Tervaert, J.W., Goldschmeding, R., Elema, J.D., Van der Giessen, M., Huitema, M.G., Van der Hem, G.K., The, T.H., von dem Borne, A.E.G.Kr., and Kallenberg, C.G.M., 1990, Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis, Kidney Int. 37: 799–806.CrossRefGoogle Scholar
  2. Goldschmeding, R., van der Schoot, C.E., Cohen Tervaert, J.W., Mason, D.Y., von dem Borne, A.E.G.Kr., and Kallenberg, C.G.M., 1988, Autoantibodies against myeloid lysosomal enzymes: a novel class of autoantibodies associated with vasculitic syndromes, Kidneylnt. 34: 588.Google Scholar
  3. Hardarson, S., LaBreque, D.R., Mitros,F.A., Neil, G., Goeken, J.A., 1991, Anti-neutrophil cytoplasmic antibody (ANCA) associated with ulcerative colitis and primary sclerosing cholangitis, Gastroenterology 100: A609.Google Scholar
  4. Kao, R.C., Wehner, N.G., Skubitz, K.M., Gray, B.H., Hoidal, J.R., 1988, Proteinse 3: a distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters, J.CIin.Invest. 82: 1963–1973.CrossRefGoogle Scholar
  5. Skogh, T., Dahlgren, C., Holmgren, K., Peen, E., and Stendahl, O., 1991, Anti-granulocyte antibodies (C-ANCA, P-ANCA, GS-ANA) studied by confocal scanning laser fluorescence microscopy, ELISA, and chemiluminescence techniques, Scand J. Immunol 34: 137–145PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Phataraporn Teeraratkul
    • 1
  • John A. Thorson
    • 1
  • John D. Kemp
    • 1
  • James A. Goeken
    • 1
  1. 1.Department of PathologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA

Personalised recommendations