Prevalence of ANCAs in Patients on Maintenance Haemodialysis

  • S. Weidemann
  • S. Apenberg
  • K. Andrassy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


ANCA analysis as evaluated by concomitant determination of ANCA-IF, PR3AB and MPO-AB in a larger cohort of dialysis patients disclosed that the prevalence of Wegener’s granulomatosis and microscopic polyarteritis in Germany is 4 fold higher than hitherto believed. Low ANCA-IF titers without measurable PR3-AB or MPO-AB are not pathological-they resemble an increased autoimmune tendency of the dialysis patients.

According to the european dialysis and transplantation association (EDTA)registry the incidence of Wegener’s granulomatosis (WG) and microscopic polyarteritis (MP) on haemodialysis (HD) in Germany is 0.5% and the prevalence is in the same range (1), In contrast to Germany the incidence in France and Great Britain is above 2%. This is mainly based on histologically proven diseases, which can identify only 1/3 of all affected cases, corresponding to our own experience. With the advent of ANCA serology, WG and MP can be diagnosed more easily. C-ANCA with proteinase 3-antibodies (PR3-AB) is typical of WG, and p-ANCA with myeloperoxidaseantibodies (MPO-AB) is typical of MP in our country. Since a considerable number of patients are on chronic HD without knowledge of their underlying renal disease we studied the prevalence of ANCAs in a larger cohort of HD patients.


Dialysis Patient Polycystic Kidney Disease Crescentic Glomerulonephritis Analgesic Nephropathy Systemic necrotiZing Vasculitis 
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  1. 1.
    Combined report on regular dialysis and transplantation in Europe XIX 1988, 1989, Nephrol.Dial.Transpl.4, Supp1. 4Google Scholar
  2. 2.
    Rasmussen,N., Sjölin, C., Isaksson, B., Bygren, P., Wieslander, J. 1990, An Elisa for the detection of antineutrophil cytoplasm antibodies, J.Immunol.Meth. 127: 139–145CrossRefGoogle Scholar
  3. 3.
    Nolph, K.D.,Ghods, A.J., Sharp, G.C., Siemsen, A.W.,1978, Antibodies to nuclear antigens in patients with renal failure, J.Lab.Clin.Med. 91: 559–567Google Scholar
  4. 4.
    Mayet, W.J., Wandel, E., Herman, E., Meyer zum Büschenfelde, K.H.,1988, Autoantikörper bei chronischen Dialysepatienten, Nieren, and Hochdruckkrankheiten 17: 381Google Scholar
  5. 5.
    Andrassy, K., Koderisch, J., Schäfer, A., Waldherr, R., 1990, Idiopathic rapidly progressive crescentic glomerulonephritis with myeloperoxidase antibodies - a new entitiy linked to female sex? Nephron 56: 99–100PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • S. Weidemann
    • 1
  • S. Apenberg
    • 1
  • K. Andrassy
    • 1
  1. 1.Department of MedicineUniversity of HeidelbergGermany

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