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Increased Expression of CD 25 and Adhesion Molecules on Peripheral Blood Lymphocytes of Patients with Wegener’s Granulomatosis (WG) and ANCA Positive Vasculitides

  • J. Gutfleisch
  • E. Baumert
  • G. Wolff-Vorbeck
  • M. Schlesier
  • H. J. Strutz
  • H. H. Peter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Peripheral blood lymphocytes of 29 c-ANCA positive WG patients fulfilling the ACR classification criteria were examined for the expression of various leukocyte surface molecules by dual marker cytofluorometry (FACStar, Becton Dickinson). Activation markers such as CD25, HLA-DR, CD29 and adhesion molecules (ICAM-1 and LFA-3) were clearly elevated in this group in comparison to 40 healthy volunteers. Similar results were obtained for p-ANCA positives vasculitides (n=13) and, unexpectedly, also for patients suffering from cholesteatoma, a chronic, bacterial infection of the middle ear (n=21). The results are discussed in view of a pathogenic model for WG and vasculitic disorders.

Keywords

Peripheral Blood Lymphocyte Lysosomal Enzyme Common Variable Immunodeficiency Antineutrophil Cytoplasmic Autoantibody Vasculitic Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. Gutfleisch
    • 1
  • E. Baumert
    • 1
  • G. Wolff-Vorbeck
    • 1
  • M. Schlesier
    • 1
  • H. J. Strutz
    • 2
  • H. H. Peter
    • 1
  1. 1.Division Rheumatology & Clinical Immunology, Dept. MedicineUniv. Hospital FreiburgGermany
  2. 2.Dept. ORLUniv. Hospital FreiburgGermany

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