Antibodies to Neutrophil Cytoplasmic Antigens in Rheumatoid Arthritis

  • Peter J. Charles
  • Ravinder N. Maini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


In this study we examined the sera from 42 randomly selected patients with RA. ANCA was demonstrated by indirect immunofluorescence on human granulocytes in 10 patients with active disease and in none of the patients with inactive disease. ELISA’s for the detection of specific antigens showed the presence of anti-myeloperoxidase in 3 patients, and anti-lactoferrin in 1 patient. The specificity of the remaining antibodies was unidentified. All 3 patients with antibodies to myeloperoxidase had vasculitis.


Rheumatoid Arthritis HL60 Cell Indirect Immunofluorescence Inactive Disease Charing Cross Hospital 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Peter J. Charles
    • 1
  • Ravinder N. Maini
    • 1
  1. 1.Department of RheumatologyCharing Cross Hospital and Kennedy Institute of RheumatologyLondonUK

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