Anti-Neutrophil Cytoplasmic Antibodies in Giant Cell Arteritis and Polymyalgia Rheumatica

  • Hans A. Cats
  • Jan Willem Cohen Tervaert
  • Roelie van Wijk
  • Piet C. Limburg
  • Cees G. M. Kallenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Antineutrophil cytoplasmic antibodies (ANCA) were demonstrated in all sera from 11 patients with active giant cell arteritis (GCA) using indirect immunofluorescence on 9% paraformaldehyde(PF)-fixed neutrophils according to Pryzwanski (median titer 1:256, range 1:64 to 1:512). After treatment during inactive disease titers decreased in all sera. Eight out of 9 sera from patients with active polymyalgia rheumatica (PMR) produced a cytoplasmic staining on Pryzwanski-fixed neutrophils in low titers (median titer 1:16, range 0 to 1:32), as did 8 out of 25 sera from healthy blood donors. None of the sera were positive for antibodies to defined antigens, i.e. proteinase-3, human leucocyte elastase, myeloperoxidase and lactoferrin as detected by ELISA. GCA seems to be associated with ANCA of as yet unknown specificity.

Keywords

Giant Cell Arteritis Juvenile Rheumatoid Arthritis Healthy Blood Donor Antineutrophil Cytoplasmic Antibody Polymyalgia Rheumatica 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Hans A. Cats
    • 1
  • Jan Willem Cohen Tervaert
    • 1
  • Roelie van Wijk
    • 1
  • Piet C. Limburg
    • 1
  • Cees G. M. Kallenberg
    • 1
  1. 1.Department of Internal MedicineUniversity HospitalGroningenThe Netherlands

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