Anti-Neutrophil Cytoplasmic Antibodies (ANCA) and Infection

  • Jean Louis Mege
  • Jean Christophe Escallier
  • Christian Capo
  • Pierre Bongrand
  • Jean Gabriel Velut
  • Nathalie Quiles
  • Jacques Soubeyrand
  • Jean Marc Durand
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

As ANCA are occasionally noted in patients with infectious disorders independently of any vasculitis process, we examined serum from patients with acute infection (n=22) and septic shock (n=57). Only two patients with acute infection were ANCA positive as determined by indirect immunofluorescence and western blot analysis. The clinical recovery of both patients was associated with negative immunofluorescence and western blot tests.

Keywords

Septic Shock Acute Infection Antineutrophil Cytoplasmic Antibody Western Blot Test High Molecular Weight Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Efthimiou, J., Spickett, G., Lane, D., and Thompson, A., 1991, Antineutrophil cytoplasmic antibodies, cytic fibrosis and infection, Lancet 1: 1037–1038.CrossRefGoogle Scholar
  2. Falk, R.J., 1990, ANCA-associated renal disease, Kidney Int. 38: 998–1010.PubMedCrossRefGoogle Scholar
  3. Goeken, J.A., 1991, Antineutrophil cytoplasmic antibody-A useful serological marker for vasculitis, J. Clin. Immunol. 11: 161–174.Google Scholar
  4. Koderish, J., Andrassy, K., Rasmussen, N., Hartmann, M., and Tilgen W., 1990, False positive antineutrophil cytoplasmic antibodies in HIV infection, Lancet 1: 1227–1229.CrossRefGoogle Scholar
  5. Meyer, K. C., and Homburger, H.A., 1991, Antineutrophil cytoplasmic antibodies in cystic fibrosis, Lancet 2: 1217–1218.CrossRefGoogle Scholar
  6. Savige, J.A., Gallichio, M., Georgiou, T., and Davies D.J., 1990, Diverse target antigens recognized by circulating antibodies in anti-neutrophil cytoplasm antibody-associated renal vasculitides, Clin. Exp. Immunol. 82: 238–243.PubMedCrossRefGoogle Scholar
  7. Van der Woude, F.J., Rasmussen, N., Lobatto, S., Wiik, A., Permin H., and Van Es, L.A., 1985, Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener’s granulomatosis, Lancet 1: 425–429.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jean Louis Mege
    • 1
  • Jean Christophe Escallier
    • 1
  • Christian Capo
    • 1
  • Pierre Bongrand
    • 1
  • Jean Gabriel Velut
    • 2
  • Nathalie Quiles
    • 2
  • Jacques Soubeyrand
    • 2
  • Jean Marc Durand
    • 2
  1. 1.Laboratory of ImmunologyHopital de Sainte-MargueriteMarseille Cedex 09France
  2. 2.Department of Internal MedicineHopital de Sainte-MargueriteMarseille Cedex 09France

Personalised recommendations