Anti-Neutrophil Cytoplasm Antibodies in HIV Infection
Sera from 105 HIV-infected patients were tested for anti-neutrophil cytoplasm antibodies (ANCA) by indirect immunofluorescence (IIF), by specific ELISAs using target proteins of ANCA and by a neutrophil cytoplasm extract ELISA. Forty-four sera were positive. These included 18 positive by IIF, 7 with anti-neutrophil proteinase 3 antibodies, 26 with anti-myeloperoxidase antibodies and 2 with anti-elastase antibodies. Four sera were positive in the neutrophil cytoplasm extract ELISA but not in the specific ELISAs. None of these patients had clinical evidence of a cutaneous or systemic vasculitis. In addition there was no correlation between the presence of ANCA and the stage of disease, intercurrent bacterial or viral infection, anti-nuclear antibodies (ANA) and positive hepatitis B or syphilis serology.
KeywordsSystemic Vasculitis Intercurrent Infection Lymphomatoid Granulomatosis Syphilis Serology Neutrophil Proteinase
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- 2.Koderisch,., Andrassy, K., Rasmussen, N., Hartmann, M. and Tilgen, W., 1990, “False-positive” antineutrophil cytoplasmic antibodies in HIV infection, Lancet. 335:1227–1228.Google Scholar
- 3.Davenport, A. and Grant, P.J., 1991, False positive autoantibodies in HIV infection, Nephron: 515–516.Google Scholar
- 4.Klaassen, R.J.L., Goldsclunedding, R., Dolman, K. M., Vlekke, A.B.J., Weigel, H.M., Eeftinck Schattenkerk, J.K.M., Mulder, J.W., Westedt, M.L., and von dem Borne, A.E.G.Kr., 1992, Antineutrophil cytoplasmic autoantibodies in patients with symptomatic HIV infection. Clin Exp Immunol. 87: 24–30.PubMedCrossRefGoogle Scholar