Anti-Neutrophil Cytoplasm Antibodies in HIV Infection

  • J. A. Savige
  • L. Chang
  • S. M. Crowe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


Sera from 105 HIV-infected patients were tested for anti-neutrophil cytoplasm antibodies (ANCA) by indirect immunofluorescence (IIF), by specific ELISAs using target proteins of ANCA and by a neutrophil cytoplasm extract ELISA. Forty-four sera were positive. These included 18 positive by IIF, 7 with anti-neutrophil proteinase 3 antibodies, 26 with anti-myeloperoxidase antibodies and 2 with anti-elastase antibodies. Four sera were positive in the neutrophil cytoplasm extract ELISA but not in the specific ELISAs. None of these patients had clinical evidence of a cutaneous or systemic vasculitis. In addition there was no correlation between the presence of ANCA and the stage of disease, intercurrent bacterial or viral infection, anti-nuclear antibodies (ANA) and positive hepatitis B or syphilis serology.


Systemic Vasculitis Intercurrent Infection Lymphomatoid Granulomatosis Syphilis Serology Neutrophil Proteinase 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. A. Savige
    • 1
  • L. Chang
    • 2
  • S. M. Crowe
    • 3
  1. 1.University Department of MedicineAustin HospitalHeidelbergAustralia
  2. 2.Department of HaematologyRepatriation General HospitalHeidelbergAustralia
  3. 3.MacFarlane Burnet Centre for Medical ResearchFairfieldAustralia

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