Pro- and Anti-Inflammatory Cytokines in Primary Systemic Vasculitis

  • Jörn Kekow
  • Christof H. Szymkowiak
  • Michael Sticherling
  • Jens-M. Schröder
  • Enno Christophers
  • Wolfgang L. Gross
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

The expression of cytokines that are potentially involved in the pathogenesis of vasculitis was studied in patients with primary systemic vasculitis (PSV). In extension of earlier reports, we detected an overexpression of transforming growth factor B (TGFB), interleukin 6 (IL6), and interleukin 8 (IL8), indicating that the whole cytokine cascade is activated to a significant extent in PSV.

Keywords

Granuloma Formation Primary Systemic Vasculitis Antineutrophil Cytoplasmic Autoantibody Neutrophil Activate Peptide Control Rheumatoid Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burrows, L.J., Piper, P.J., Lindley, I.D., and Westwick, J., 1991, Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086, Ann.N. Y.Acad.Sci. 629: 422.PubMedCrossRefGoogle Scholar
  2. Gross, W.L., Csernok, E., and Schmitt, W.H., 1991, Antineutrophil cytoplasmic autoantibodies: Immunobiological aspects, Klin. Wochenschr. 69: 558.PubMedCrossRefGoogle Scholar
  3. Kekow, J., Wachsman, W., McCutchan, J.A., Cronin, M., Carson, D.A., and Lotz, M., 1990, Transforming growth factor ß and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection, ProcNatl.Acad.Sci. USA. 87: 8321.CrossRefGoogle Scholar
  4. Mrowietz, U., Sticherling, M., Mielke, V., Schröder, J.-M., and Christophers, E., 1991, Neutrophilactivating peptide 1/interleukin 8 mRNA expression and protein secretion by human monocytes: Effect of cyclosporin A, Cytokine3: 322.Google Scholar
  5. Sheron, N. and Williams, R., 1992, IL-8 as a circulating cytokine: Induction by recombinant tumor necrosis factor-alpha, CIin.Exp.Immunol 89: 100.CrossRefGoogle Scholar
  6. Zhou, D., Munster, A., and Winchurch, R.A., 1991, Pathologic concentration of interleukin 6 inhibit T-cell responses via induction of activation of TGFB, FASEBJ. 5: 2582.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jörn Kekow
    • 1
    • 2
  • Christof H. Szymkowiak
    • 1
    • 2
  • Michael Sticherling
    • 3
  • Jens-M. Schröder
    • 3
  • Enno Christophers
    • 3
  • Wolfgang L. Gross
    • 1
    • 2
  1. 1.Department of Clinical RheumatologyMedical University at LübeckBad BramstedtGermany
  2. 2.Department of MedicineRheumaklinik Bad Bramstedt GmbHBad BramstedtGermany
  3. 3.Department of DermatologyUniversity of KielKielGermany

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