Low Predictive Value of C-ANCA and Anti-α -Granule Antibody for Vasculitis in Hong Kong

  • John W. M. Lawton
  • S. S. Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


One thousand sera, not previously tested for ANCA, were assayed for C-ANCA and anti-a-granule antibody. There was low concordance (23%) between the two assays in terms of positivity. Each assay gave a positive predictive value for systemic vasculitis (excluding SLE and other connective-tissue diseases) of not more than 20%.


Kawasaki Disease Systemic Vasculitis Antineutrophil Cytoplasmic Antibody Normal Seron Positive ANCA 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • John W. M. Lawton
    • 1
  • S. S. Lee
    • 2
  1. 1.Department of PathologyUniversity of Hong KongHong Kong
  2. 2.Department of HealthHong Kong

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