Autoantibodies Directed Against Lysozyme: A New Target Antigen for Anti-Neutrophil Cytoplasmic Antibodies (ANCA)

  • Wilhelm H. Schmitt
  • Elena Csernok
  • Brigitte K. Flesch
  • Stefanie Hauschild
  • Wolfgang L. Gross
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Abstract

ANCA-positive sera from 1138 patients and ANCA-negative sera from 90 patients were screened for autoantibodies directed against lysozyme (LZ) by ELISA. Sera from 120 patients did react with LZ. 99 sera bound to LZ only, whereas 56 sera bound to further granule proteins, especially cathepsin G and lactoferrin. In the routine ANCA screening, most of the anti-LZ-positive sera showed a pANCA fluorescence. In total, 8% of 674 pANCA-positive sera did react with LZ. Clinically, anti-LZ antibodies were associated inflammatory rheumatologic,-renal and-bowel diseases.

Keywords

Systemic Lupus Erythematosus Ulcerative Colitis Giant Cell Arteritis Target Antigen Mixed Connective Tissue Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Wilhelm H. Schmitt
    • 1
  • Elena Csernok
    • 1
  • Brigitte K. Flesch
    • 1
  • Stefanie Hauschild
    • 1
  • Wolfgang L. Gross
    • 1
  1. 1.Department of Rheumatology Medical University of Lübeck and Medical DepartmentRheumaklinik Bad Bramstedt GmbHGermany

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