Summary
In a prospective study of 27 months duration p-ANCA were found in 120 patients. 35% of these patients had vasculitis and/or glomerulonephritis. 28% of the p-ANCA positive sera reacted with myeloid lysosomal enzymes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Goldschmeding R, Cohen Tervaert JW, Schoot CE, Veen C, Kallenberg CGM, Borne AEGK, 1989, ANCA, anti-myeloperoxidase, and elastase: three members of a novel class of autoantibodies against myeloid lysosomal enzymes. Proceedings of the istinternational workshop on ANCA, Copenhagen 1988, APMIS. 97: (S6) 48–49.
Falk RJ, Jennette JC, 1989, Immunofluorescence and ELISA determination of ANCA with description of a sub-class with anti-myeloperoxidase activity. Proceedings of the 1st international workshop on ANCA, Copenhagen 1988, APMIS. 97: (S6) 45.
Falk RJ, Jennette JC, 1988, Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. NEngl JMed. 318: 1651–1657.
Cohen Tervaert JW, Goldschmeding R, Elema JD, Giessen M, Huitema MG, Koolen MI, Hene RJ, The TH, Hem GK, Kallenberg CGM, 1990, Association of autoantibodies to myeloperoxidase with different forms of vasculitis. Arthritis Rheum. 33: 1264–1272.
Duerr RH, Targan SR, Landers CJ, LaRusso NF, Lindsay KL, Wiesner RH, Shanahan F, 1991, Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 100: 1385–1391.
Cohen Tervaert JW, Mulder AHL, Horst G, Haagsma EB, Kleibeuker JH, Kallenberg CGM, 1992, Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis, ulcerative colitis, and autoimmune liver diseases. Gastroenterology 102: 1090.
Cohen Tervaert JW, Goldschmeding R, Elema JD, van der Giessen M, Huitema MG, van der Hem GK, von dem Borne AEGKr, Kallenberg CGM, 1990, Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis. Kidney Int. 37: 799–806.
Cohen Tervaert JW, Limburg PC, Elema JD, Huitema MG, Horst G, The TH, Kallenberg CGM, 1991, Detection of autoantibodies against myeloid lysosomal enzymes: A useful adjunct to classification of patients with biopsy-proven necrotizing arteritis. Am JMed. 91: 59–66.
Venning MC, Quinn A, Broomhead V, Bird AG, 1990, Antibodies directed against neutrophils (CANCA and P-ANCA) are of distinct diagnostic value in systemic vasculitis. QJMed 77: 1287–1296.
Calabresi P, Edwards EA, Schilling RF, 1959, Fluorescent antiglobulin studies in leukopenic and related disorders. JClin Invest. 38: 2091–2100.
Calabresi P, Thayer WR, Spiro HM, 1961, Demonstration of circulating antinuclear globulins in ulcerative colitis. JClin Invest. 40: 2126–2133.
Wiik A, 1980, Granulocyte-specific antinuclear antibodies. Possible significance for the pathogenesis, clinical features and diagnosis of rheumatoid arthritis. Allergy 35: 263–289.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Tervaert, J.W.C., Mulder, A.H.L., Kallenberg, C.G.M. (1993). Perinuclear Antineutrophil Cytoplasmic Antibodies (P-ANCA): Clinical Significance and Relation to Antibodies Against Myeloid Lysosomal Enzymes. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_37
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9182-2_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9184-6
Online ISBN: 978-1-4757-9182-2
eBook Packages: Springer Book Archive