Perinuclear Antineutrophil Cytoplasmic Antibodies (P-ANCA): Clinical Significance and Relation to Antibodies Against Myeloid Lysosomal Enzymes

  • Jan Willem Cohen Tervaert
  • A. H. Leontine Mulder
  • Cees G. M. Kallenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


In a prospective study of 27 months duration p-ANCA were found in 120 patients. 35% of these patients had vasculitis and/or glomerulonephritis. 28% of the p-ANCA positive sera reacted with myeloid lysosomal enzymes.


Systemic Lupus Erythematosus Ulcerative Colitis Primary Sclerosing Cholangitis Churg Strauss Syndrome Crescentic Glomerulonephritis 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jan Willem Cohen Tervaert
    • 1
  • A. H. Leontine Mulder
    • 1
  • Cees G. M. Kallenberg
    • 1
  1. 1.Department of Clinical ImmunologyUniversity Hospital GroningenThe Netherlands

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