Neutrophilic Leukocyte Granules: From Structure to Function

  • Dorothy Ford Bainton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


The ability of each type of leukocyte to perform its special function depends on the synthesis of particular chemical substances during its maturation. Certain leukocytes, e.g., the granulocytes, synthesize proteins at regular intervals early in their maturation in bone marrow and store them for days in large cytoplasmic granules (Bainton and Farquhar 1966, 1970; Bainton et al., 1971). When appropriately stimulated, these cells can move from blood to tissues and, within seconds, the granules may release their contents into an endocytic vacuole or, by fusion with the plasma membrane, to the exterior of the cell. Thus, their major function in inflammatory processes is usually accomplished by endocytosis “eating”, or exocytosis “secreting” (Bainton, 1980).


Human Neutrophil Ultrastructural Localization Specific Granule Human Polymorphonuclear Leukocyte Bactericidal Permeability Increase 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Dorothy Ford Bainton
    • 1
  1. 1.Department of PathologyUniversity of CaliforniaSan FranciscoUSA

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