Induction of an Humoral and Cellular (Auto) Immune Response to Human and Rat Myeloperoxidase(MPO) in Brown-Norway(BN), Lewis and Wistar Kyoto(WKY) Rat Strains

  • Elisabeth Brouwer
  • Jan J. Weening
  • Pieter A. Klok
  • Minke G. Huitema
  • Jan Willem Cohen Tervaert
  • Cees G. M. Kallenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Anti-MPO and anti-proteinase 3 antibodies are strongly associated with certain forms of vasculitis and glomerulonephritis and a pathophysiological role for the antibodies has been hypothesized (Kallenberg et al. 1991). To test this hypothesis WKY, Lewis and BN rats were immunized with human MPO. BN rats developed a strong humoral response, cross reacting with autologous MPO, and Lewis rats a strong cellular response to human MPO.

Keywords

Pathophysiological Role Concentration Of20 Lymphocyte Stimulation Test Strong Humoral Response Humoral Autoimmune Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kallenberg C.G.M., Cohen Tervaert J.W., Woude F.J. van der, Goldschmeding R., Borne A.E.G.Kr. von dem, Weening J.J. (1991) Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulunephritis? Immunology Today 12 (2): 61–64.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Elisabeth Brouwer
    • 1
  • Jan J. Weening
    • 2
  • Pieter A. Klok
    • 3
  • Minke G. Huitema
    • 1
  • Jan Willem Cohen Tervaert
    • 4
  • Cees G. M. Kallenberg
    • 1
  1. 1.Dept. Clinical ImmunologyUniversity Hospital GroningenThe Netherlands
  2. 2.Dept. PathologyUniversity Hospital AmsterdamThe Netherlands
  3. 3.Dept. PathologyUniversity Hospital GroningenThe Netherlands
  4. 4.Vascular Research Div.Dept. PathologyBostonUSA

Personalised recommendations