Summary
The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. We describe some preliminary experiments on the effect of transfer of serum from mercuric chloride treated rats and of two forms of immunotherapy: intravenous immunoglobulin and an anti-CD4 antibody. Transfer of serum did not lead to tissue injury and neither of the two forms of therapy proved beneficial in this model.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hirsch F., Couderc J., Sapin C., Fournie G., Druet P., 1982, Polyclonal effect of mercuric chloride in the rat, its possible role in an experimental autoimmune disease.Eur.J.Immunol. 12: 620–625.
Pelletier L., Pasquier R., Hirsch F., Sapin C., Druet P.,1986, Autoreactive T cells in mercury-induced autoimmune disease: in vitro demonstration. J.Immunol. 137: 2548–2554.
Pelletier L., Pasquier R., Rossert J., Vial M-C., Druet P.,1988, Autoreactive T cells in mercury induced autoimmunity: ability to induce the autoimmune disease, J.Immuno1. 140: 750–754.
Sapin C., Druet E., Druet P., 1977, Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride, Clin.Exp.Immunol. 28: 173–179.
Aten J., Veninga A., de Heer E., et al., 1991, Susceptibility to the induction of either autoimmunity or or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur.J.Immuno1. 21: 611–616.
Mathieson P., Thiru S., Oliveira D., 1992, Mercuric chloride treated Brown Norway rats develop widespread tissue injury including necrotizing vasculitis, Lab.Invest. 67: 121–129.
Esnault V., Mathieson P., Thiru S., Oliveira D., Lockwood C., 1992, Autoantibodies to myeloperoxidase and necrotizing vasculitis in Brown Norway rats treated with mercuric chloride, Lab.Invest. 67: 114–120.
Rossi F., Bellon B., Vial M., Druet P., Kazatchkine M., 1991, Clin. Exp.Immunol., 84: 129–133.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Qasim, F.J., Mathieson, P.W., Thiru, S., Oliveira, D.B.G., Lockwood, C.M. (1993). Further Characterization of an Animal Model of Systemic Vasculitis. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_23
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9182-2_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9184-6
Online ISBN: 978-1-4757-9182-2
eBook Packages: Springer Book Archive