Endothelium, Myeloperoxidase, Anti-Myeloperoxidase Interaction in Vasculitis

  • M. Varagunam
  • D. Adu
  • C. M. Taylor
  • J. Michael
  • N. Richards
  • J. Neuberger
  • R. A. Thompson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

We report that myeloperoxidase(MPO) binds to endothelium probably by a charge mechanism and can in turn be bound by antibodies to myeloperoxidase.

Keywords

Lupus Nephritis Crescentic Glomerulonephritis Direct Staining Stimulate Tumor Necrosis Factor Microscopic Polyarteritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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  2. Falk R.J. and Jennette J.C.,1988, Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotising and crescentic glomerulonephritis. N Engl J Med 318: 1651–1657PubMedCrossRefGoogle Scholar
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  4. Lee S.S., Adu D., Thompson R.A.,1990, Anti-myeloperoxidase antibodies in systemic vasculitis. Clin Exp Immunol. 79: 41PubMedCrossRefGoogle Scholar
  5. Varagunam M., Adu D., Taylor C.M., Michael J., Neuberger J., Richards N., MyeloperoxidaseEndothelium -Anti-myeloperoxidase interaction in vasculitis. Nephrol Dial Transplant (in press)Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. Varagunam
    • 1
  • D. Adu
    • 1
  • C. M. Taylor
    • 1
  • J. Michael
    • 1
  • N. Richards
    • 1
  • J. Neuberger
    • 2
  • R. A. Thompson
    • 3
  1. 1.Renal Research LaboratoryUK
  2. 2.Liver LaboratoryUK
  3. 3.Queen Elizabeth Hospital Edgbaston Birmingham B15 2TH Regional Immunology LaboratoryEast Birmingham HospitalUK

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