Summary
c-ANCA recognise target autoantigens present in HL-60 cells and neutrophils, of which the 29kD protein (derived from both cell types) exhibits N-terminal sequence homology.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bories, D., Raynal, M-C., Solomon, D.H., Darzynkiewicz, Z., Cayre, Y.E. 1989. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukaemia cells. Cell 59: 959–968
Charles, L.A., Falk, R.J., Jennette, J.C. 1989. Reactivity of anti-neutrophil cytoplasmic autoantibodies with HL-60 cells. Clin.Immunol.Immunopathol. 53: 243–253
Gupta, S.K., Niles, J.L., McCluskey, R.T., Arnaout, M.A. 1990. Identity of Wegener’s autoantigen (p29) with proteinase 3 and myeloblastin. blood 76: 2162
Jenne, D.E., Tschopp, J., Ludemann, J., Utecht, B., Gross, W.L. 1990. Wegener’s autoantigen decoded. Nature 346: 520
Jones, S.J., Lockwood, C.M. 1990. Characterisation of autoantigens in systemic vasculitis. Kidney Int. 37: 441 (Abstract)
Labbaye, C., Musette, P., Cayre, Y.E. 1991. Wegener autoantigen and myeloblastin are encoded by a single mRNA. Proc.Natl.Acad.Sci.USA 88: 9253–9256
Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685
Matsudaira, P. 1987. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J.Biol.Chem. 262: 10035–10038
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jones, S.J., Lockwood, C.M. (1993). ANCA Specificities for HL-60 and Neutrophil Constituents. In: Gross, W.L. (eds) ANCA-Associated Vasculitides. Advances in Experimental Medicine and Biology, vol 336. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9182-2_17
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9182-2_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9184-6
Online ISBN: 978-1-4757-9182-2
eBook Packages: Springer Book Archive