ANCA and IgG Subclasses

  • Mårten Segelmark
  • Jörgen Wieslander
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)


We studied IgG subclass distribution of ANCA in 247 patients with ELISA. We used monoclonal subclass specific antibodies and purified MPO and proteinase 3 as antigen. We found that IgG1 and IgG4 yield high values in both groups. We also found that high IgG2 titers were rare among the anti-proteinase 3 positive, while it was common among anti-MPO sera. In the assays for IgG3 the situation was the opposite.


Positive Seron Rapidly Progressive Glomerulonephritis Alpha Granule Antineutrophil Cytoplasmic Autoantibody High IgG2 Titer 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Mårten Segelmark
    • 1
  • Jörgen Wieslander
    • 2
  1. 1.Department of NephrologyUniversity of LundLundSweden
  2. 2.Statens Serum InstitutCopenhagenDenmark

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