Population Diversity of Point Mutations in the Human AChE and BCHE Genes Predicts Variable Responses to Anticholinesterase Drugs

  • Gal Ehrlich
  • Dalia Ginzberg
  • Mikael Schwarz
  • Yael Loewenstein
  • David Glick
  • BatSheva Kerem
  • Shlomi Ben-Ari
  • Haim Zakut
  • Hermona Soreq
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

On an experimental basis, patients with neurodegenerative diseases receive anti-cholinesterases (Iversen, 1993; Enz et al., 1993; Giacobini, 1993) to improve cognitive function (Alzheimer’s disease) or to reduce muscle spasms (Parkinson’s disease). These drugs are directed toward the nervous system acetyl- and butyrylcholinesterase (AChE, BuChE). However, the response of specific individuals to such drugs was found to be highly variable. Molecular genetics findings strongly suggest that this variability may be due to genomic diversity in the corresponding genes, primarily in the BuChE gene, BCHE.

Keywords

Jewish Population Serum Cholinesterase Anticholinesterase Agent Somatic Hybrid Cell Panel Molecular Genetic Finding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Gal Ehrlich
    • 1
  • Dalia Ginzberg
    • 1
  • Mikael Schwarz
    • 1
  • Yael Loewenstein
    • 1
  • David Glick
    • 1
  • BatSheva Kerem
    • 2
  • Shlomi Ben-Ari
    • 3
  • Haim Zakut
    • 3
  • Hermona Soreq
    • 1
  1. 1.The Departments of GeneticsThe Institute of Life Sciences The Hebrew UniversityJerusalemIsrael
  2. 2.The Biological Chemistry and GeneticsThe Institute of Life Sciences The Hebrew UniversityJerusalemIsrael
  3. 3.Department of Obstetrics and Gynecology The Sackler Faculty of MedicineTel-Aviv University Wolfson Medical CenterHolonIsrael

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