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Effect of Chronic Administration of 1,2,3,4-Tetrahydroisoquinoline and Its Derivatives on the Monkey: Immunohistochemical Study

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Part of the Advances in Behavioral Biology book series (ABBI,volume 44)

Abstract

Since 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to produce symptoms similar to Parkinson’s disease (Langston et al., 1983), toxins with structure similar to MPTP have been hypothesized to result in cell death of mesencephalic dopamine neurons. 1,2,3,4-Tetrahydroisoquinoline (TIQ) has a structure similar to MPTP, and it, and its derivatives exist as endogenous amines in human brain (Ohta et al., 1987; Niwa et al., 1987; Niwa et al., 1989). Toxic properties of TIQ on mitochondria are similar to those of MPP+ (the oxidative product of MPTP) (Suzuki et al., 1988). N-methyltetrahydroisoquinoline (NMTIQ) is formed from TIQ by N-methyltransferase (Naoi et al., 1989a). NMTIQ is oxidized by both type A and B monoamine oxidases, and the N-methylisoquinolinium ion (NMIQ+), the oxidative product, inhibits activities of enzymes related to catecholamine metabolism (Naoi et al., 1989b). NMTIQ and NMIQ+ inhibits complex I activity, similarly to TIQ, and this inhibitory potency of NMIQ+ on complex I activity is stronger than that of MPP+ (Suzuki et al., 1992). Recently, we administered TIQ and its derivatives (NMTIQ and NMIQ+) to monkeys and observed mesencephalic dopamine neurons immunohistochemically. Using light and electron microscopy we found that NMTIQ produces changes in mesencephalic dopamine neurons.

Keywords

  • Inclusion Body
  • Monoamine Oxidase
  • Biogenic Amine
  • Diaminobenzidine Tetrahydrochloride
  • Immunoreactive Neuron

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Forno, L.S., Langston, J.W., Delaney, L.E., and Irwin, I., 1988, An electron microscopic study of MPTPinduced inclusion bodies in an old monkey, Brain Res. 448: 150.

    PubMed  CrossRef  CAS  Google Scholar 

  • Langston, J.W., Ballard, P., Tetrud, J.W., and Irwin, I., 1983, Chronic parkinsonism in humans due to a product of meperidine-analog synthesis, Science 219: 979.

    PubMed  CrossRef  CAS  Google Scholar 

  • Nagatsu, L, 1983, Immunohistocytochemistry of biogenic amines and immunoenzyme-histocytochemistry of catecholamine-synthesizing enzymes: application for axoplasmic transport and neuronal localization, in: “Methods in Biogenic Amine Research, S. Parvez, T. Nagatsu, I. Nagatsu, and H. Parvez, eds., Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Naoi, M., Matsuura, S., Takahashi, T., and Nagatsu, T., 1989a, A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion, BBRC 161: 1213.

    PubMed  CAS  Google Scholar 

  • Naoi, M., Matsuura, S., Parvez, H., Takahashi, T., Hirata, Y., Minami, M., and Nagatsu, T., 1989b, Oxidation of N-methyl-1,2,3,4-tetrahydroisoquinoline into the N-methyl-isoquinolinium ion by monoamine oxidase, J. Neurochem. 52: 653.

    PubMed  CrossRef  CAS  Google Scholar 

  • Niijima, K., Araki, M., Ogawa, M., Suzuki, K., Mizuno, Y., Nagatsu, I., Kimura, H., Yoshida, M., and Nagatsu, T., 1991, N-methylisoquinoliniumion (NMIQ’) destroys cultured mesencephalic dopamine neurons, Biogenic Amines 8: 61

    CAS  Google Scholar 

  • Niwa, T., Takeda, N., Kaneda, N., Hashizume, Y., and Nagatsu, T., 1987, Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroisoquinoline in parkinsonian and normal human brains, BBRC 144: 1084.

    PubMed  CAS  Google Scholar 

  • Niwa, T., Takeda, N., Sasaoka, T., Kaneda, N., Hashizume, Y., Yoshimizu, H., Tatematsu, A., and Nagatsu, T., 1989, Detection of tetrahydroisoquinoline in parkinsonian brain as an endogenous amine by use of gas chromatography-mass spectrometry, J. Chromgtogr. 491: 397.

    CrossRef  CAS  Google Scholar 

  • Ogawa, M., Araki, M., Nagatsu, I., Nagatsu, T., and Yoshida, M., 1989, The effect of 1,2,3,4-tetrahydroisoquinoline (TIQ) on mesencephalic dopaminergic neurons in C57BL/6J mice:immunohistochemical studies-tyrosine hydroxylase, Biogenic Amines 6: 427.

    CAS  Google Scholar 

  • Ohta, S., Kohno, M., Makino, Y., Tachikawa, O., and Hirobe, M., 1987, Tetrahydroisoquinoline and 1methyl-tetrahydroisoquinoline are present in the human brain: relation to parkinson’s disease, Biomed. Res. 8: 453.

    Google Scholar 

  • Schwyn, R.C., King, J.S., and Fox, C.A., 1976, Pigments in red nucleus and substantia nigra in man and in representive old and new world monkeys, Bol. Estud. Med. Biol. 139.

    Google Scholar 

  • Suzuki, K., Mizuno, Y., and Yoshida, M., 1988, Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity and ATP synthesis by tetrahydroisoquinoline, Neurosci. Lett. 86: 105.

    PubMed  CrossRef  CAS  Google Scholar 

  • Suzuki, K., Mizuno, Y., Yamauchi, Y., Nagatsu, T., and Yoshida, M., 1992, Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain, J. Neurol. Sci. 109: 219.

    PubMed  CrossRef  CAS  Google Scholar 

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Ogawa, M. et al. (1995). Effect of Chronic Administration of 1,2,3,4-Tetrahydroisoquinoline and Its Derivatives on the Monkey: Immunohistochemical Study. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_84

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  • DOI: https://doi.org/10.1007/978-1-4757-9145-7_84

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9147-1

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