Abstract
Brain perfusion evaluation by single photon emission tomography (SPECT) is useful in diagnosing patients with dementia of Alzheimer’s type (DAT).1–9 DAT, in fact, is associated with a reduction in global cerebral blood flow (CBF) and metabolism as well as a highly diagnostic finding of a bilateral and almost symmetrical decrease of CBF and metabolism in the parieto-temporal regions.10,11 However, many DAT patients with posterior parieto-temporal flow reduction also have diffuse flow decrease in the frontal cortex area, usually of somewhat asymmetric distribution.12 The temporo-parietal flow reduction is often very asymmetric13,14 with the dominant neurological deficit usually localized on the most affected side of the brain, i.e. with aphasia dominating in the left-sided cases and visuo-spatial apraxia in the right-sided cases.15,16
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. Postiglione, N. A. Lassen, and B. L. Holman, Cerebral blood flow in patients with dementia of Alzheimer’s type, Aging Clin. Exper. Res. 5: 19 (1993).
M. B. Cohen, L. S. Graham, R. Lake, E. J. Metter, J. Fitten, M. K. Kulkami, R. Sevrin, L. Yamada, C. C. Chang, and N. Woodruff, Diagnosis of Alzheimer’s disease and multiple infarct dementia by tomographic imaging of iodine-123 IMP, J. Nucl. Med. 27: 769 (1986).
P. Sharp, H. Gemmell, G. Cherryman, J. Besson, J. Crawford, and F. Smith, Application of iodine 123-labeled isopropylamphetamine imaging in the study of dementia, J. Nucl. Med. 27: 761 (1986).
F. W. Smith, H. G. Gemmell, and P. F. Sharp, The use of Tc-99m-HM-PAO for the diagnosis of dementia, Nucl. Med. Commun. 8: 525 (1987).
W. J. Jagust, T. F. Budinger, and B. R. Reed, The diagnosis of dementia with single photon emission computed tomography, Arch. Neurol. 44: 258 (1987).
D. Neary, J. S. Snowden, R. A. Shields, A. W. I. Burjan, B. Northern, N. McDermott, M. C. Prescott, and H. J. Testa, Single photon emission tomography using Tc-99m-HM-PAO in the investigation of dementia, J. Neurol. Neurosurg. Psychiatry 50: 1101 (1987).
K. A. Johnson, S. T. Mueller, T. M. Walshe, R. J. English, and B. L. Holman, Cerebral perfusion imaging in Alzheimer’s disease: use of single photon emission computed tomography and iofetamine hydrochloride I-123, Arch. Neurol. 44: 165 (1987).
D. Perani, V. DiPiero, G. Vallar, S. Cappa, C. Messa, G. Bottini, A. Berti, D. Passalume, G. Scarlato, P. Gerundini, G. L. Lenzi, and F. Fazio, Technetium-99m-HM-PAO-SPECT study of regional cerebral perfusion in early Alzheimer’s disease, J. Nucl. Med. 29: 1507 (1988).
F. J. Bonte, E. D. Ross, H. H. Chebabi, and M. D. Devous, SPECT study of regional cerebral blood flow in Alzheimer’s disease, J. Compia. Assist. Tomogr. 10: 579 (1986).
H. G. Gemmel, P. E. Sharp, J. A. O. Besson, J. R. Crawford, K. P. Ebmeier, J. Davidson, and F. W. Smith, Differential diagnosis in dementia using the cerebral blood flow agent 99mTc-HMPAO: a SPECT study, J. Comput. Assist. Tomogr. 11: 398 (1987).
B. L. Holman, K. A. Johnson, B. Garada, P. A. Carvalho, and A. Satlin, The scintigraphic appearance of Alzheimer’s disease: a prospective study using technetium-99m-HMPAO-SPECT, J. Nucl. Med. 33: 181 (1992).
J. V. Haxby, C. L. Grady, B. Horvitz, M. Shapiro, R. P. Friedl, and S. I. Rapaport, Heterogeneous anterior-posterior metabolic patterns in dementia of Alzheimer’s type, Neurology 38: 1853 (1988).
J. V. Haxby, R. Duara, C. L. Grady, N. R. Cutler, and S. I. Rapaport, Relations between neuropsychological and cerebral metabolic asymmetry in early Alzheimer’s disease, J. Cereb. Blood Flow Metab. 6: 193 (1985).
P. Celsis, A. Agniel, M. Puel, LeTinnier, G. Vaillard, J. F. Demonet, A. Rascol, and J. P. Marc-Vergnes, Lateral asymmetries in primary degenerative dementia of Alzheimer’s type. A correlative study of cognitive,haemodynamic and EEG data, in relation with severity, age, of onset and sex, Cortex 26: 585 (1990).
B. L. Holman, R. Gibson, T. Hill, W. Eckelman, M. Albert, and R. Reba, Muscarinic acetylcholine receptors in Alzheimer’s disease, JAMA 254: 3063 (1985).
A. Burns, M. P. Philpot, D. C. Costa, P. EII, and R. Levy, The investigation of Alzheimer’s disuse with single photon emission tomography, J. Neurol. Neurosurg. Psychiatry 52: 248 (1989).
K. P. Ebmeier, R. Hunter, C. L. Murray, N. J. Dougall, R. E. O’Carroll, and G. M. Goodwin, Unilateral voluntary hand movement and regional uptake of 99mTc-exametazime in human control subjects, J. Nucl. Med. 33: 1637 (1992).
K. J. Shedlack, R. Hunter, D. Wyper, R. McLuskie, G. Fink, and G. M. Goodwin, The pattern of cerebral activity underlying verbal fluency by split-dose single photon emission tomography (SPET or SPECT) in normal volunteers, Psychol. Med. 21: 687 (1991).
J. D. Miller, M. J. DeLeon, and S. H. Ferris, Abnormal temporal lobe response in Alzheimer’s disease during cognitive processing as measured by 11-C-2-deoxy-D-glucose and PET, J. Cereb. Blood Flow Metab. 7: 248 (1987).
J. Kessler, K. Herholz, M. Grond, and W. D. Heiss, Impaired metabolic activation in Alzheimer’s disease: a PET study during continuous visual recognition, Neuropsychologia 29: 229 (1991).
R. Duara, W. W. Barker, J. Chen, F. Yoshii, D. A. Loewenstein, and S. Pascal, Viability of neocortical function shown in Behavioral activation state PET studies in Alzheimer disease, J. Cereb. Blood Flow Metab. 12: 927 (1992).
G. McKahn, D. Drachman, M. Folstein, R. Katzman, D. Price, and E. M. Stadlan, Clinical diagnosis of Alzheimer’s disease-report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease, Neurology 34: 939 (1984).
B. Reisberg, S. H. Ferris, M. J. DeLeon, and T. Crook, The Global Deterioration Scale for assessment of primary degenerative dementia, Am. J. Psych. 139: 1136 (1982).
G. Waldemar, S. G. Hasselbach, A. R. Anderson, F. Delecluse, P. Petersen, A. Johnson, and O. B. Paulson, 99Tc-d,l-HMPAO and SPECT of the brain in normal aging, J. Cereb. Blood Flow Metab. 11: 508 (1991).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Postiglione, A. et al. (1995). Cerebral Blood Flow at Rest and During Cognitive Activation in Patients with Moderate Dementia of Alzheimer’s Type. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_8
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9145-7_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9147-1
Online ISBN: 978-1-4757-9145-7
eBook Packages: Springer Book Archive