Abstract
Alzheimer’s disease (AD) was originally reserved for dementia in patients with presenile onset of symptoms. It was considered a cortical disorder with a parieto-temporallobe symptomatology (Blennow and Wallin, 1992). Since the 1960s, largely based on the histopathological observation that neurofibrillary tangles and senile plaques are found in the brains of senile dementia patients, these disorders have been named senile dementia of the Alzheimer type (SDAT) and sampled together with AD as Alzheimer-type dementia. However, in SDAT, the symptomatology is more general and/or of a subcortical type, indicating subcortical damage (Blennow and Wallin, 1992).
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References
Blennow, K., and Wallin, A., 1992, Clinical heterogeneity of probable Alzheimer’s disease, J. Geriatr. Psychiatry Neurol. 5: 106.
Blennow, K., Davidsson, P., Wallin, A., Fredman, P., Gottfries, C.G., Manson, J.E., and Svennerholm, L., 1992, Differences in cerebrospinal fluid gangliosides between “probable Alzheimer’s disease” and normal aging, Aging 4: 301.
Blennow, K., Davidsson, O., Wallin, A., Fredman, P., Gottfries, C.G., Karlsson, I., Manson, J.E., and Svennerholm, L., 1991, Gangliosides in cerebrospinal fluid in ‘probable Alzheimer’s diseisko, Arch. Neurol. 48: 1032.
Gottfries, C.G., Adolfsson, R., Aquilonius, S.M., Carlsson, A., Eckernis, S.A., Nordberg, A., Oreland, L., Svennerholm, L., Wiberg, A., and Winblad, B., 1983, Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT), Neurobiol. Aging 4: 261.
Ledeen, R.W., 1984, Biology of gangliosides: neuritogenic and neuronotrophic properties, J. Neurosci. 12: 147.
Svennerholm, L., and Gottfries, C.G., 1993, Membrane lipids selectively diminished in Alzheimer brains suggest synapse loss as primary event in early onset form (Type I) and demyelination in late onset form (Type II), Neurochemistry,in press.
Svennerholm, L., Gottfries, C.G., Blennow, K., Fredman, P., Karlsson, I., Manson, J.E., Toffano, G., Wallin, and A., 1990, Parenteral administration of GM1 ganglioside to presenile Alzheimer patients, Acta Neurol. Scand. 81: 48.
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© 1995 Springer Science+Business Media New York
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Gottfries, C.G. (1995). Gangliosides and Alzheimer’s Disease. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_74
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DOI: https://doi.org/10.1007/978-1-4757-9145-7_74
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