Gangliosides and Alzheimer’s Disease
Alzheimer’s disease (AD) was originally reserved for dementia in patients with presenile onset of symptoms. It was considered a cortical disorder with a parieto-temporallobe symptomatology (Blennow and Wallin, 1992). Since the 1960s, largely based on the histopathological observation that neurofibrillary tangles and senile plaques are found in the brains of senile dementia patients, these disorders have been named senile dementia of the Alzheimer type (SDAT) and sampled together with AD as Alzheimer-type dementia. However, in SDAT, the symptomatology is more general and/or of a subcortical type, indicating subcortical damage (Blennow and Wallin, 1992).
KeywordsCaudate Nucleus Frontal White Matter Myelin Lipid Postmortem Investigation Frontal Grey Matter
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