Abstract
Xanomeline (3-(4-Hexyloxy-1,2,5-thiadiazole-3-yl)-1,2,5,6-tetrahydro-1- methylpyridine), (hexyloxy-TZTP) was discovered in the course of investigations on the structure activity relationship of a series of thiadiazole based analogs of the muscarinic agonist arecoline. The compound demonstrated functional selectivity for M1 receptors when tested in isolated tissue preparations and in cloned cell lines expressing specific muscarinic receptor subtypes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mitch, C.H. et al. (1995). Xanomeline: A Potent and Selective M1 Muscarinic Agonist in Vitro. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_66
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9145-7_66
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9147-1
Online ISBN: 978-1-4757-9145-7
eBook Packages: Springer Book Archive