Alzheimer Disease: Major Neurotransmitter Deficits. Can they be Corrected?

  • Ezio Giacobini
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


During the several year progression of Alzheimer disease (AD), a continuous loss of neurons is observed in two major forebrain nuclei of the central nervous system (CNS): the locus coeruleus (LC) and the nucleus basalis of Meynert (NBM). Numerous neuropathological and biochemical studies of AD brain have revealed a substantial decrease of noradrenergic neurons in the LC and a 70% depletion of norepinephrine (NE) in the cortex (cf. Nazarali and Reynolds, 1992). The serotonergic system is also affected (cf. Nazarali and Reynolds, 1992).


Alzheimer Disease Locus Coeruleus AChE Activity Cholinergic Neuron AChE Inhibition 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Ezio Giacobini
    • 1
  1. 1.Department of PharmacologySouthern Illinois University School of MedicineSpringfieldUSA

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