Catecholamine-Containing Biodegradable Microsphere Implants: An Overview of Experimental Studies in Dopamine-Lesioned Rats

  • Amanda McRae
  • Annica Dahlström
  • Stephan Hjorth
  • Eng Ang Ling
  • David Mason
  • Thomas Tice
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


The main neurochemical characteristic of Parkinson’s disease (PD) is a marked lesion of the nigro-striatal dopamine pathway. In attempts to provide dopamine replacement therapy to Parkinson’s patients, the current medication is L-DOPA (Birkmayer and Hornykiewicz, 1961). Dopamine (DA) itself cannot be taken orally because it will not reach the brain. Unfortunately, L-DOPA can cause serious adverse reactions and its effectiveness decreases with time. For these reasons, there has been an increasing demand for and interest in novel techniques for site-directed delivery of substances into the central nervous system (CNS) (Stahl, 1984).


Rotational Behavior Fiber Growth Experimental Parkinsonism Oculogyric Crisis Nerve Growth Factor Content 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Amanda McRae
    • 1
  • Annica Dahlström
    • 1
  • Stephan Hjorth
    • 2
  • Eng Ang Ling
    • 3
  • David Mason
    • 4
  • Thomas Tice
    • 4
  1. 1.Department of Anatomy and Cell BiologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of PharmacologyUniversity of GöteborgGöteborgSweden
  3. 3.Department of AnatomyNational University of SingaporeSingapore 0511Singapore
  4. 4.Southern Research InstituteBirminghamUSA

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