Intracerebroventricular Injection of Streptozotocin — An Animal Model for Sporadic Alzheimer’s Disease?

  • Dorothea Müller
  • Konstanze Plaschke
  • Siegfried Hoyer
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


In normoglycemic patients with either incipient early-onset or incipient late-onset dementia of the Alzheimer type (DAT), the predominant disturbance consists of a significant reduction in cerebral glucose utilization. Cerebral blood flow and oxygen consumption is changed only in late-onset dementia types and is most severely decreased in advanced late-onset dementia (Hoyer et al.,1991). Reductions in resting state regional brain metabolism are roughly proportional to the severity of dementia. These reductions are greater in association than in primary sensory and motor neocortical regions and correlate with the distribution of neuropathology and cell loss after death (for review, see Rapoport, 1991).


Phosphoglycerate Mutase Cerebral Glucose Utilization Glycolytic Enzyme Activity Normoglycemic Patient Diabetogenic Drug 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Dorothea Müller
    • 1
  • Konstanze Plaschke
    • 1
  • Siegfried Hoyer
    • 1
  1. 1.Department of Pathochemistry and General NeurochemistryUniversity of HeidelbergHeidelbergGermany

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