The Cholinotoxin AF64A Differentially Attenuates in Vitro Transcription of the Human Cholinesterase Genes

  • I. Hanin
  • A. Yaron
  • D. Ginzberg
  • H. Soreq
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


Numerous reports in the literature have now demonstrated that ethylcholine aziridinium (AF64A) exerts selective cholinotoxicity, in vivo, in a number of animal species.1,2 These effects are dose-and time-dependent and reversible, when low concentrations of AF64A (e.g. ≤ 2 nmol/lateral ventricle in the rat) are used.3 The dose range for cholinoselectivity of AF64A needs to be established accurately with each specific application, since there is an upper dose limit at which AF64A begins to exert nonspecific degenerative effects.1


AChE Activity Choline Acetyltransferase Ache Gene Cholinergic Nerve Terminal Transcription Vector 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • I. Hanin
    • 1
  • A. Yaron
  • D. Ginzberg
    • 2
  • H. Soreq
    • 2
  1. 1.Department of PharmacologyLoyola University Chicago Stritch School of MedicineMaywoodUSA
  2. 2.The Department of Biological Chemistry The Life Sciences InstituteHebrew UniversityJerusalemIsrael

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