Cell Wall-Defective Forms of Nocardia Asteroides Require Tetrahydrobiopterin for Their Growth

  • Shunro Kohbata
  • Ryoichi Hayashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


An L-dopa-responsive movement disorder with Lewy-like body shares many features with patients suffering from Parkinson’s disease (Kohbata and Beaman, 1991). The cause of Parkinson’s disease remains unknown. An encephalitic virus has been proposed to be an etiologic agent for Parkinson’s disease. Following the pandemic of von Economo’ encephalitis lethargica, many patients were left with clinical features resembling Parkinson’s disease (Caine and Langston, 1983). Numerous attempts to isolate an infective agent were undertaken; some claims were made that a filterable, transmissible and glycerol-resistant microorganisms had been isolated, but it was non-cultivatable on ordinary media under either aerobic or anaerobic conditions (Flexner, 1923).


Ferrous Sulfate Brain Heart Infusion Brain Heart Infusion Broth Nutrient Factor Rigid Cell Wall 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Shunro Kohbata
    • 1
  • Ryoichi Hayashi
    • 2
  1. 1.Department of MicrobiologyGifu University School of MedicineGifu 500Japan
  2. 2.Department of Medicine (Neurology)Shunshu University School of MedicineMatsumoto 390Japan

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