The Effect of Acetylcholinesterase Inhibitors on Acetylcholinesterase in Senile Plaque, Normal Human or Rat Brain, Human Erythrocyte or Rat Skeletal Muscle

  • S. Nakamura
  • M. Yukawa
  • Y. Mimori
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


The cholinergic system is affected in the brain of patients with Alzheimer’s disease, depleting choline acetyltransferase and acetylcholinesterase (AChE). Histochemical studies on AChE distribution in the cerebral cortex have revealed a difference between control subjects and Alzheimer patients.’ We have also demonstrated biochemically the difference in the subcellular distribution of AChE between control subjects and Alzheimer patients.2 The highest specific activity of AChE was detected in the fraction enriched with senile plaque.’


Alzheimer Patient AChE Activity Alzheimer Brain Senile Plaque Supernatant Solution 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • S. Nakamura
    • 1
  • M. Yukawa
    • 1
  • Y. Mimori
    • 1
  1. 1.Third Dept of Internal MedicineHiroshima University School of MedicineHiroshima 734Japan

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