Acetylcholinesterase is Not a Protease: Implications for Alzheimer’s Disease

  • Mark R. Emmerling
  • Jacques Grassi
  • Richard T. Carroll
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


Acetylcholinesterase (AChE) has been alleged for over a decade to possess a protease activity. The activity was first described in purified eel AChE from commercial suppliers and bovine serum AChE (Chubb et al., 1980; Chubb et al., 1983). Two protease activities appear to reside with the AChE, a trypsin-like endopeptidase and a carboxypeptidase (Small et al., 1987; Small, 1988). The protease activity is difficult to remove from the AChE indicating that it is either tightly bound or intrinsic to the enzyme (Small, 1989; Small, 1990). However, a recent report suggests that bovine serum AChE is reversibly associated with a protease activity (Michaelson and Small, 1993).


High Performance Liquid Chromatography Protease Activity AChE Activity Velocity Sedimentation Electric Organ 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Mark R. Emmerling
    • 1
  • Jacques Grassi
    • 2
  • Richard T. Carroll
    • 1
  1. 1.Neuroscience PharmacologyParke-Davis Pharmaceutical ResearchAnn ArborUSA
  2. 2.Service de Pharmacologie et d’ImmunologieC.E. SaclayGif sur YvetteFrance

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