Skip to main content

Effect of Cholinergic Enhancers on Basal Forebrain Function Governing Cortical Cerebral Blood Flow

  • Chapter
Alzheimer’s and Parkinson’s Diseases

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 44))

  • 15 Accesses

Abstract

Among the losses of brain functions in Alzheimers disease (AD) are reductions in cerebral blood flow (CBF), decrements in cerebral glucose utilization and abnormal electrocorticograms (Dastur, 1985; Petit et al., 1983). Topographically, these impaired brain functions correspond to the loss of the cholinergic innervation to the cortex and hippocampus arising out of the basal forebrain (BF) (Bartus et al., 1982).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Apud, J.A., 1993, The 5-HT, receptor in mammalian brain, A new target for the development of psychotropic drugs? Neuropsychopharmacology 8: 117.

    Article  PubMed  CAS  Google Scholar 

  • Americ, S.P., 1989, Cortical cerebral blood flow is modulated by cholinergic basal forebrain neurons: effects of ibotinic acid lesions and electrical stimulation, in: “Neurotransmission and Cerebrovascular Function”, J. Seylaz and E.T. Mackenzie, eds., Vol. 1, Excerpts Medica International Congress Series, 381–384.

    Google Scholar 

  • Arneric, S.P., and Williams, M., 1993, Nicotinic agonist in Alzheimer’s Disease: Does the molecular diversity of nicotine receptors offer the opportunity for developing CNS selective cholinergie channel activators? in: “Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Function’, G. Racagni, N. Brunello, S.Z. Langer, eds., Capri, Italy.

    Google Scholar 

  • Aubert, I., Araujo, D.M., Cecyre, D., Robitaille, Y., Gauthier, S., and Quirion, R., 1992, Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer’s and Parkinson’s diseases, J. Neurochem. 58: 529–541.

    Article  PubMed  CAS  Google Scholar 

  • Barnes, J.M., Barnes, N.M., Costall, B., Naylor, R.J., and Tyers, M.B., 1989, 5-HT, receptors mediates inhibition of acetylcholine release in cortical tissue, Nature 338: 762–763.

    Google Scholar 

  • Barnes, J.M., Costall, B., Coughlan, J., Doweney, A.M., Gerrard, P.A., Kelly, M.E., Naylor, R.J., Onaivi, E.S., Tomkins, D.M., and Tyers, M.B, 1990, The effects of ondansetron, a 5-HT, receptor antagonist, on cognition in rodents and primates, Pharmacol. Biochem. Behay. 35: 955–962.

    Article  CAS  Google Scholar 

  • Bartus, R.T., Dean, R.L., III, Beer, B., Lipps, A.S., 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science 217: 408.

    Article  PubMed  CAS  Google Scholar 

  • Benowitz, N.L., 1992, Nicotine and coronary heart disease, Trends Cardiovasc. Med. 1: 315–321.

    Article  Google Scholar 

  • Briggs, C.A., Sullivan, J.P., Decker, M.W., Brioni, J.D., Raszkiewicz, J.L., Hughes, M., Buckley, M.J., and Arneric, S.P., 1994, (+)2-Methylpiperidine: An Allosteric Modulator of Neuronal Nicotinic

    Google Scholar 

  • Acetylcholine Receptor Function, J. Pharmacol. Exp. Therap. (In Preparation). Cook, L., Nickolson, V.J., Steinfels, G.F., Rohrbach, K.W., and DeNoble, V.J., 1990, Cognition enhancement by the acetylcholine releaser DuP 99, Drug Devel. Res. 19:301–314.

    Google Scholar 

  • Dastur, D.K., 1985, Cerebral blood flow and metabolism in normal human aging, pathological aging and senile dementia, J. Cerebral Blood Flow & Metabol. 5: 1.

    Article  CAS  Google Scholar 

  • Dauphin, F., Lacombe, P., Sercombe, R., Hamel, E. and Seylaz, J., 1991, Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms, Brain Res. 553: 75.

    Article  PubMed  CAS  Google Scholar 

  • Decker, M.W., and McGaugh, J.L., 1991, The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory, Synapse 7: 151–168.

    Article  PubMed  CAS  Google Scholar 

  • Decker, M.W., Majchrzak, M.J., and Arneric, S.P., 1993, Effects of lobeline, a nicotinic receptor agonist, on learning and memory, Pharm. Biochem and Behay ., 45: 571

    Article  CAS  Google Scholar 

  • Dent, G.W., Rule, B.L., Tam, W.S., and DeSouza, E.B., 1993, Effects of the memory enhancer linopiridine (DuP 996) on cerebral glucose metabolism in naive and hypoxia-exposed rats, Brain Res. 620: 7.

    Article  PubMed  CAS  Google Scholar 

  • Gitelman D.R., and Prohovnik, I., 1992, Muscarinic and nicotinic contributions to cognitive function and cortical blood flow, Neurobiol. Aging 13: 313–318.

    Article  PubMed  CAS  Google Scholar 

  • Kilpatrick, G.J., Jones, B.J., and Tyers, M.B., 1988, The distribution of specific binding of the 5-HT3 receptor ligand [3H] GR65630 in rat brain using quantitative autoradiography, Neurosci. Lett. 94: 156–160.

    Article  PubMed  CAS  Google Scholar 

  • Kimura, A., Sato, A., Takano, Y., 1990, Stimulation of the nucleus basalis of Meynert does not influence glucose utilization of the cerebral cortex in anesthetized rats, Neurosci. Lett. 119: 109.

    Google Scholar 

  • Levin, E.D., 1992, Nicotinic systems in cognitive function, Psychopharmacology 108: 417–431.

    Article  PubMed  CAS  Google Scholar 

  • Linville, D.G., Williams, S., Raszkiewicz, J.L., and Arneric, S.P., 1993, Nicotinic agonists modulate basal

    Google Scholar 

  • forebrain control of cortical cerebral blood flow in anesthetized rats, J. Pharm. Exp. Ther. 267:4.40–448. Linville, D.G., and Arneric, S.P., 1991, Cortical cerebral blood flow governed by the basal forebrain: agerelated impairments, Neurobiol. Aging 12:503–510.

    Google Scholar 

  • Marchi, M., Raiteri, M., 1984, On the presence in the cerebral cortex of muscarinic receptor subtypes that differ in neuronal localization, function and pharmcological properties, J. Pharm. Exp. Ther. 235: 230.

    Google Scholar 

  • Nickolson, V.G., Tam, S.W., Myers, M.J., Cook, L., 1990, DuP 996 [3,3-bis[4-pyrindinylmethyl]-1phenylindoline-2–1-one] enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo, Drug Dev. Res. 19: 285.

    Article  CAS  Google Scholar 

  • Petit, D., Lorrain, D., Gauthier, S., Montplaisir, J., 1993, Regional spectral analysis of the REM sleep EEG in mild to moderate Alzheimer’s disease, Neurobiol. Aging 14: 141.

    Article  PubMed  CAS  Google Scholar 

  • Pomponi, M., Giacobini, E., Brufani, M., 1990, Present state and future development of the therapy of Alzheimer’s disease, Neurobiol. Aging 2: 125.

    CAS  Google Scholar 

  • Raszkiewicz, J.L., Linville, D.G., Kerwin, J.F., Jr., Wagenaar, F., and Arneric, S.P., 1992, Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation, J. Neurosci. Res. 33: 129–135.

    Article  PubMed  CAS  Google Scholar 

  • Risberg, J., Gustafson, L., and Brun, A., 1990, High resolution regional cerebral blood flow measurements in Alzheimer’s disease and other dementia disorders in Alzheimer’s Disease, in: “Epidemiology, Neuropathology, Neurochemistry, and Clinics”, L. Maurer, P. Riederer, H. Beckmann, eds., Springer-Verlag, Berlin 509–516.

    Chapter  Google Scholar 

  • Sargent, P.B., 1993, The diversity of neuronal nicotinic acetylcholine receptors, Ann. Rev. Neurosci. 16: 403–443.

    Article  PubMed  CAS  Google Scholar 

  • Sloan, J.W., Martin, W.R., Hook, R., Bostwick, M., Howell, A., Smith, W.T., 1985, Stereospecificity of 2-methylpiperidine binding to a nicotinic up-regulatory site in the rat brain P2 preparation, Life Sci. 37: 1367.

    Article  PubMed  CAS  Google Scholar 

  • Soldatos, C.R., Kales, J.D., Scharf, M.B., Bixler, E.O., and Kales, A., 1980, Cigarette smoking associated with sleep difficulty, Science 207: 551–553.

    Article  PubMed  CAS  Google Scholar 

  • Sunderland, T., Tariot, P.N., and Newhouse, P.A., 1988, Differential responsivity of mood, behavior and

    Google Scholar 

  • cognition to cholinergic agonists in elderly neuropsychiatric populations, Brain Res. Rev. 13:371–389.

    Google Scholar 

  • White, A., Corn, T.H., Feetman, C., and Faulconbridge, C., 1991, Ondansetron in treatment of schizophrenia, Lancet 337: 1173.

    Google Scholar 

  • Wonnacott, S., Irons, J. Rapier, C., Thorne, B., and Lnt, G.G., 1990, Presynaptic modulation of transmitter release by nicotinic receptors, in: “Progress in Brain Research’, Amsterdam: Elsevier, pp. 157–163.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Raszkiewicz, J.L., Sullivan, J.P., Arneric, S.P. (1995). Effect of Cholinergic Enhancers on Basal Forebrain Function Governing Cortical Cerebral Blood Flow. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_38

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9145-7_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9147-1

  • Online ISBN: 978-1-4757-9145-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics