Abstract
Among the losses of brain functions in Alzheimers disease (AD) are reductions in cerebral blood flow (CBF), decrements in cerebral glucose utilization and abnormal electrocorticograms (Dastur, 1985; Petit et al., 1983). Topographically, these impaired brain functions correspond to the loss of the cholinergic innervation to the cortex and hippocampus arising out of the basal forebrain (BF) (Bartus et al., 1982).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Apud, J.A., 1993, The 5-HT, receptor in mammalian brain, A new target for the development of psychotropic drugs? Neuropsychopharmacology 8: 117.
Americ, S.P., 1989, Cortical cerebral blood flow is modulated by cholinergic basal forebrain neurons: effects of ibotinic acid lesions and electrical stimulation, in: “Neurotransmission and Cerebrovascular Function”, J. Seylaz and E.T. Mackenzie, eds., Vol. 1, Excerpts Medica International Congress Series, 381–384.
Arneric, S.P., and Williams, M., 1993, Nicotinic agonist in Alzheimer’s Disease: Does the molecular diversity of nicotine receptors offer the opportunity for developing CNS selective cholinergie channel activators? in: “Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Function’, G. Racagni, N. Brunello, S.Z. Langer, eds., Capri, Italy.
Aubert, I., Araujo, D.M., Cecyre, D., Robitaille, Y., Gauthier, S., and Quirion, R., 1992, Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer’s and Parkinson’s diseases, J. Neurochem. 58: 529–541.
Barnes, J.M., Barnes, N.M., Costall, B., Naylor, R.J., and Tyers, M.B., 1989, 5-HT, receptors mediates inhibition of acetylcholine release in cortical tissue, Nature 338: 762–763.
Barnes, J.M., Costall, B., Coughlan, J., Doweney, A.M., Gerrard, P.A., Kelly, M.E., Naylor, R.J., Onaivi, E.S., Tomkins, D.M., and Tyers, M.B, 1990, The effects of ondansetron, a 5-HT, receptor antagonist, on cognition in rodents and primates, Pharmacol. Biochem. Behay. 35: 955–962.
Bartus, R.T., Dean, R.L., III, Beer, B., Lipps, A.S., 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science 217: 408.
Benowitz, N.L., 1992, Nicotine and coronary heart disease, Trends Cardiovasc. Med. 1: 315–321.
Briggs, C.A., Sullivan, J.P., Decker, M.W., Brioni, J.D., Raszkiewicz, J.L., Hughes, M., Buckley, M.J., and Arneric, S.P., 1994, (+)2-Methylpiperidine: An Allosteric Modulator of Neuronal Nicotinic
Acetylcholine Receptor Function, J. Pharmacol. Exp. Therap. (In Preparation). Cook, L., Nickolson, V.J., Steinfels, G.F., Rohrbach, K.W., and DeNoble, V.J., 1990, Cognition enhancement by the acetylcholine releaser DuP 99, Drug Devel. Res. 19:301–314.
Dastur, D.K., 1985, Cerebral blood flow and metabolism in normal human aging, pathological aging and senile dementia, J. Cerebral Blood Flow & Metabol. 5: 1.
Dauphin, F., Lacombe, P., Sercombe, R., Hamel, E. and Seylaz, J., 1991, Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms, Brain Res. 553: 75.
Decker, M.W., and McGaugh, J.L., 1991, The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory, Synapse 7: 151–168.
Decker, M.W., Majchrzak, M.J., and Arneric, S.P., 1993, Effects of lobeline, a nicotinic receptor agonist, on learning and memory, Pharm. Biochem and Behay ., 45: 571
Dent, G.W., Rule, B.L., Tam, W.S., and DeSouza, E.B., 1993, Effects of the memory enhancer linopiridine (DuP 996) on cerebral glucose metabolism in naive and hypoxia-exposed rats, Brain Res. 620: 7.
Gitelman D.R., and Prohovnik, I., 1992, Muscarinic and nicotinic contributions to cognitive function and cortical blood flow, Neurobiol. Aging 13: 313–318.
Kilpatrick, G.J., Jones, B.J., and Tyers, M.B., 1988, The distribution of specific binding of the 5-HT3 receptor ligand [3H] GR65630 in rat brain using quantitative autoradiography, Neurosci. Lett. 94: 156–160.
Kimura, A., Sato, A., Takano, Y., 1990, Stimulation of the nucleus basalis of Meynert does not influence glucose utilization of the cerebral cortex in anesthetized rats, Neurosci. Lett. 119: 109.
Levin, E.D., 1992, Nicotinic systems in cognitive function, Psychopharmacology 108: 417–431.
Linville, D.G., Williams, S., Raszkiewicz, J.L., and Arneric, S.P., 1993, Nicotinic agonists modulate basal
forebrain control of cortical cerebral blood flow in anesthetized rats, J. Pharm. Exp. Ther. 267:4.40–448. Linville, D.G., and Arneric, S.P., 1991, Cortical cerebral blood flow governed by the basal forebrain: agerelated impairments, Neurobiol. Aging 12:503–510.
Marchi, M., Raiteri, M., 1984, On the presence in the cerebral cortex of muscarinic receptor subtypes that differ in neuronal localization, function and pharmcological properties, J. Pharm. Exp. Ther. 235: 230.
Nickolson, V.G., Tam, S.W., Myers, M.J., Cook, L., 1990, DuP 996 [3,3-bis[4-pyrindinylmethyl]-1phenylindoline-2–1-one] enhances the stimulus-induced release of acetylcholine from rat brain in vitro and in vivo, Drug Dev. Res. 19: 285.
Petit, D., Lorrain, D., Gauthier, S., Montplaisir, J., 1993, Regional spectral analysis of the REM sleep EEG in mild to moderate Alzheimer’s disease, Neurobiol. Aging 14: 141.
Pomponi, M., Giacobini, E., Brufani, M., 1990, Present state and future development of the therapy of Alzheimer’s disease, Neurobiol. Aging 2: 125.
Raszkiewicz, J.L., Linville, D.G., Kerwin, J.F., Jr., Wagenaar, F., and Arneric, S.P., 1992, Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation, J. Neurosci. Res. 33: 129–135.
Risberg, J., Gustafson, L., and Brun, A., 1990, High resolution regional cerebral blood flow measurements in Alzheimer’s disease and other dementia disorders in Alzheimer’s Disease, in: “Epidemiology, Neuropathology, Neurochemistry, and Clinics”, L. Maurer, P. Riederer, H. Beckmann, eds., Springer-Verlag, Berlin 509–516.
Sargent, P.B., 1993, The diversity of neuronal nicotinic acetylcholine receptors, Ann. Rev. Neurosci. 16: 403–443.
Sloan, J.W., Martin, W.R., Hook, R., Bostwick, M., Howell, A., Smith, W.T., 1985, Stereospecificity of 2-methylpiperidine binding to a nicotinic up-regulatory site in the rat brain P2 preparation, Life Sci. 37: 1367.
Soldatos, C.R., Kales, J.D., Scharf, M.B., Bixler, E.O., and Kales, A., 1980, Cigarette smoking associated with sleep difficulty, Science 207: 551–553.
Sunderland, T., Tariot, P.N., and Newhouse, P.A., 1988, Differential responsivity of mood, behavior and
cognition to cholinergic agonists in elderly neuropsychiatric populations, Brain Res. Rev. 13:371–389.
White, A., Corn, T.H., Feetman, C., and Faulconbridge, C., 1991, Ondansetron in treatment of schizophrenia, Lancet 337: 1173.
Wonnacott, S., Irons, J. Rapier, C., Thorne, B., and Lnt, G.G., 1990, Presynaptic modulation of transmitter release by nicotinic receptors, in: “Progress in Brain Research’, Amsterdam: Elsevier, pp. 157–163.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Raszkiewicz, J.L., Sullivan, J.P., Arneric, S.P. (1995). Effect of Cholinergic Enhancers on Basal Forebrain Function Governing Cortical Cerebral Blood Flow. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_38
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9145-7_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9147-1
Online ISBN: 978-1-4757-9145-7
eBook Packages: Springer Book Archive