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Alzheimer’s and Parkinson’s Diseases pp 189–196Cite as

Phenotypes and Genotypes of Apolipoprotein E in Japanese Patients with Late-Onset Sporadic Alzheimer’s Disease, Vascular Dementia, Down’s Syndrome or Parkinson’s Disease

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 44))

Abstract

Alzheimer’s disease (AD) is a major cause of dementia in the elderly. Most patients are sporadic and develop the disease after 60 years of age. Senile plaques (SP), neurofibrillary tangles (NFT) and amyloid angiopathies are observed histopathologically and the deposition of β-amyloid protein is postulated to play a crucial role in the development of AD.1 Extensive genetic studies in this late-onset AD have failed to identify any consistent abnormalities in the gene encoding amyloid precursor protein (APP) so far, and the mechanism for deposition of β-amyloid is yet to be determined.

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Author information

Authors and Affiliations

  1. Department of Neurology, USA

    Akira Ueki, Yoshio Namba & Mieko Otsuka

  2. Department of Atherosclerosis and Metabolism Jichi Medical School, Omiya Medical Center, Amanuma 1-847, Omiya City 330, Japan

    Mikihiko Kawano, Masanobu Kawakami & Masayo Matsumura

  3. Division of Medical Genetics, Saitama Children’s Medical Center, Magome 2100, Iwatsuki City 339, Japan

    Yoshimitsu Fukushima

  4. Department of Ultrastructure, Tokyo Institute of Psychiatry, Kamikitazawa, Tokyo 156, Japan

    Kazuhiko Ikeda

Authors
  1. Akira Ueki
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  2. Mikihiko Kawano
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  3. Yoshio Namba
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  4. Masanobu Kawakami
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  5. Masayo Matsumura
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  6. Yoshimitsu Fukushima
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  7. Mieko Otsuka
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  8. Kazuhiko Ikeda
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Editor information

Editors and Affiliations

  1. Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA

    Israel Hanin Ph.D.

  2. Jichi Medical School, Tochigi, Japan

    Mitsuo Yoshida M.D.

  3. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher Ph.D.

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© 1995 Springer Science+Business Media New York

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Ueki, A. et al. (1995). Phenotypes and Genotypes of Apolipoprotein E in Japanese Patients with Late-Onset Sporadic Alzheimer’s Disease, Vascular Dementia, Down’s Syndrome or Parkinson’s Disease. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9145-7_28

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  • DOI: https://doi.org/10.1007/978-1-4757-9145-7_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9147-1

  • Online ISBN: 978-1-4757-9145-7

  • eBook Packages: Springer Book Archive

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