Phenotypes and Genotypes of Apolipoprotein E in Japanese Patients with Late-Onset Sporadic Alzheimer’s Disease, Vascular Dementia, Down’s Syndrome or Parkinson’s Disease

  • Akira Ueki
  • Mikihiko Kawano
  • Yoshio Namba
  • Masanobu Kawakami
  • Masayo Matsumura
  • Yoshimitsu Fukushima
  • Mieko Otsuka
  • Kazuhiko Ikeda
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


Alzheimer’s disease (AD) is a major cause of dementia in the elderly. Most patients are sporadic and develop the disease after 60 years of age. Senile plaques (SP), neurofibrillary tangles (NFT) and amyloid angiopathies are observed histopathologically and the deposition of β-amyloid protein is postulated to play a crucial role in the development of AD.1 Extensive genetic studies in this late-onset AD have failed to identify any consistent abnormalities in the gene encoding amyloid precursor protein (APP) so far, and the mechanism for deposition of β-amyloid is yet to be determined.


Amyloid Precursor Protein Vascular Dementia Senile Plaque Amyloid Precursor Protein Gene Familial Alzheimer Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Akira Ueki
    • 1
  • Mikihiko Kawano
    • 2
  • Yoshio Namba
    • 1
  • Masanobu Kawakami
    • 2
  • Masayo Matsumura
    • 2
  • Yoshimitsu Fukushima
    • 3
  • Mieko Otsuka
    • 1
  • Kazuhiko Ikeda
    • 4
  1. 1.Department of NeurologyUSA
  2. 2.Department of Atherosclerosis and Metabolism Jichi Medical SchoolOmiya Medical CenterOmiya City 330Japan
  3. 3.Division of Medical GeneticsSaitama Children’s Medical CenterIwatsuki City 339Japan
  4. 4.Department of UltrastructureTokyo Institute of PsychiatryKamikitazawa, Tokyo 156Japan

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