Effect of Ciliary Neurotrophic Factor on β-Amyloid Precursor Protein mRNA Expression
The neuropathological hallmark of Alzheimer’s disease is the progressive accumulation of senile plaques. The major constituent of senile plaques is amyloid β/A4 protein. This β/A4 peptide consists of 42–43 amino acids and is derived from a large transmembrane protein,the β-amyloid precursor protein (APP).5 The APP gene is expressed in various tissues and is highly conserved in evolution. In addition, three major isoforms (APP695, APP751, APP770) are generated from a single gene by alternative splicing, two of which (APP751,APP770) contain the Kunitz-type protease inhibitor (KPI) domain. APP is presumed to play an important role in physiological or pathological conditions. However, the mechanisms regulating APP are yet unknown.
KeywordsCiliary Neurotrophic Factor Cerebral Cortical Neuron Ciliary Ganglion Neuron Large Transmembrane Protein CNTF Treatment
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