The basal forebrain cholinergic system (BFCS) appears to be the major source of cortical cholinergic innervation. Anatomical, physiological and behavioral experiments are now beginning to unravel some of the mechanisms linking this system to complex behavior, aging and neurodegenerative processes. The BFCS has been suggested to be particularly involved in cortical activation and reorganization, learning and memory, attention, and development.
Acetylcholinesterase Inhibitor Paired Helical Filament Cholinergic Hypothesis Global Clinical Improvement Medial Septal Area
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