The Cholinergic Hypothesis of Geriatric Cognitive Dysfunction”: Consensus Meeting. January 24–25, 1993, Brescia, Italy

  • PierFranco Spano
  • Marco Trabucch
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


The basal forebrain cholinergic system (BFCS) appears to be the major source of cortical cholinergic innervation. Anatomical, physiological and behavioral experiments are now beginning to unravel some of the mechanisms linking this system to complex behavior, aging and neurodegenerative processes. The BFCS has been suggested to be particularly involved in cortical activation and reorganization, learning and memory, attention, and development.


Acetylcholinesterase Inhibitor Paired Helical Filament Cholinergic Hypothesis Global Clinical Improvement Medial Septal Area 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • PierFranco Spano
    • 1
  • Marco Trabucch
    • 2
  1. 1.Dipart. di Scienze Biomediche e Biotecnologie Sezione di Farmacologia Tossicologia e Terapia SperimentaleUniversitá degli Studi di BresciaBresciaItaly
  2. 2.RomeItaly

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