A Novel Gene Delivery System for Neuroactive Peptides in Brain Tissue

  • Edwin M. Meyer
  • Ping Wu
  • Mike King
  • Christopher M. de Fiebre
  • William J. Millard
  • Sean Bryant
  • Yu-Ping Gao
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

The development of a gene delivery system that permits long term, stable expression in brain tissue would be an important step for treating long term neuropathological disorders such as Alzheimer’s disease. Conceivably, such a system could reduce levels of neurotoxic gene-products (e.g., amyloid precursor protein) through infusion of appropriate antisenseconstructs, or counteract disease-induced losses in neurotransmission/ trophism through exogenous gene-induced peptide synthesis.

Keywords

Gene Delivery System Sendai Virus Neuroactive Peptide Region Dependent Manner Sendai Virus Envelope 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Edwin M. Meyer
    • 1
  • Ping Wu
    • 1
  • Mike King
    • 2
  • Christopher M. de Fiebre
    • 1
  • William J. Millard
    • 3
  • Sean Bryant
    • 1
  • Yu-Ping Gao
    • 1
  1. 1.Department of Pharmacology and TherapeuticsUniversity of Florida J. Hillis Miller Health CenterGainesvilleUSA
  2. 2.Department of Pharmacodynamics College of PharmacyUniversity of Florida J. Hillis Miller Health CenterGainesvilleUSA
  3. 3.Department of Neuroscience College of MedicineUniversity of Florida J. Hillis Miller Health CenterGainesvilleUSA

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