Frontal Dysfunction and Memory Deficit in Depression and Parkinson’s Disease

  • Eeva-Liisa Helkala
  • Veikko Laulumaa
  • Jaana Järvinen
  • Paavo Riekkinen
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)


Cognitive and memory impairment is a frequent finding in patients with Parkinson’s disease (PD) (Taylor et al., 1986; Growdon and Corkin, 1986) and in depression (Sternberg and Jarvik, 1976; Wertman et al., 1993). Heterogeneity of memory dysfunction in different neurological illnesses has recently raised interest. The impaired memory in the PD patients has been suggested to be an indication of mild frontal lobe dysfuntion (Taylor et al., 1986). In positron emission tomography, depression in PD has been associated with hypometabolism in the inferior frontal lobe and the caudate nucleus (Mayberg et al., 1990). Structural changes in the caudate nucleus and white matter in magnetic resonance imaging have been associated with late age onset depression (Figiel et al., 1990). Despite similar memory dysfunction, the underlying cognitive processes contributing to dysfunction may differ. We, therefore, examined working memory, learning ability, and retrieval from semantic memory and their relationship to frontal dysfunctions in PD patients, in depressive patients and in controls.


Semantic Memory Digit Span Wisconsin Card Sorting Test Significant Group Effect Frontal Lobe Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Eeva-Liisa Helkala
    • 1
  • Veikko Laulumaa
    • 1
  • Jaana Järvinen
    • 1
  • Paavo Riekkinen
    • 1
  1. 1.Department of NeurologyUniversity of KuopioKuopioFinland

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