Neuroradiologic Investigations of Alcoholism

  • D. Adrian Wilkinson


Neuroradiologic studies1,2 of alcoholics have been appearing in the scientific literature for almost 40 years. The earlier studies employed the technique of pneumoencephalography (PEG), but since the introduction in 1973 of computed tomographic (CT) scanning of the brain, it has been the preferred neuroradiologic technique.3,4 The findings from both types of study have been very consistent and show that alcoholics tend to have morphologic abnormalities of the brain. The type of abnormality observed is determined in part by the diagnostic technique used and is also affected by the criteria used in evaluating the neuroradiologic procedures5,6 Despite these variations in procedure and criteria, neuroradiologic studies consistently have shown that alcoholics tend to have abnormally wide cortical sulci and significant enlargement of the lateral and third ventricles. In addition, some investigators, using PEG and CT scan data, have reported evidence of cerebellar abnormalities in alcoholics, though this type of morphologic abnormality is less frequently reported than is enlargement of the ventricles and cortical sulci.


Compute Tomographic Scan Chronic Alcoholic Brain Damage Cerebellar Atrophy Cerebral Atrophy 
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  1. 1.
    Horvath TB: Clinical spectrum and epidemiological features of alcoholic dementia, in Rankin JG (ed): Alcohol, Drugs, and Brain Damage. Toronto, Alcoholism and Drug Addiction Research Foundation of Ontario, 1975, pp 1–16Google Scholar
  2. 2.
    Hudolin V: Impairments of the nervous system in alcoholics, in Richter D (ed): Addiction and Brain Damage. London, Croom Helm, 1980, pp 168–200Google Scholar
  3. 3.
    Cala LA, Mastaglia FL: Computerized tomography in chronic alcoholics. Alcoholism: Clin Exp Res 5: 283–294, 1981CrossRefGoogle Scholar
  4. 4.
    Wilkinson DA: Examination of alcoholics by computed tomographic (CT) scans: A critical review. Alcoholism: Clin Exp Res 6: 31–45, 1982CrossRefGoogle Scholar
  5. 5.
    Hill SY: Establishing the cut-offs for brain dysfunction using neuroradiological and neuropsychological indices: Where should we draw the line? in Wilkinson DA (ed): Cerebral Deficits in Alcoholism. Toronto, Alcoholism and Drug Addiction Research Foundation of Ontario, 1979, pp 47–59Google Scholar
  6. 6.
    Hill SY, Mikhael M: Computed tomography scans of alcoholics: Cerebral atrophy? Science 204: 1237–1238, 1979PubMedCrossRefGoogle Scholar
  7. 7.
    Probst FP: Gas distension of the lateral ventricles at encephalography. Acta Radio(14:1–4, 1973Google Scholar
  8. 8.
    Bird JM: Computerized tomography, atrophy and dementia: A review. Prog Neurobiol 19: 91–115, 1982PubMedCrossRefGoogle Scholar
  9. 9.
    Parsons OA: Neuropsychological deficits in alcoholics: Facts and fancies. Alcoholism 1: 51–56, 1977PubMedGoogle Scholar
  10. 10.
    Ron MA: Brain damage in chronic alcoholism; a neuropathological, neuroradiological and psychological review. Psycho! Med 7: 103–112, 1977CrossRefGoogle Scholar
  11. 11.
    Ambrose J: Computerized transverse axial scanning (tomography). Part 2. Clinical application. Br J Radiol 46: 1023–1047, 1973PubMedCrossRefGoogle Scholar
  12. 12.
    Hounsefield GN: Computerized transverse axial scanning (tomography): Part 1. Description of system. Br J Radio 46: 1016–1022, 1973CrossRefGoogle Scholar
  13. 13.
    Gawler J, Bull JWD, Du Boulay GH, et al: Computerized axial tomography: The normal EMI scan. J Neurol Neurosurg Psychiatry 38: 935–947, 1975PubMedCrossRefGoogle Scholar
  14. 14.
    Gawler J, Du Boulay GH, Bull JWD, et al: Computerized tomography (the EMI scanner) a comparison with pneumoencephalography and ventriculography. J Neurol Neurosurg Psychiatry 39: 203–211, 1976PubMedCrossRefGoogle Scholar
  15. 15.
    Carlen PL, Wilkinson DA, Kiraly LT: Dementia in alcoholics: A longitudinal study including some reversible aspects. Neurology (Minneap) 26: 355, 1976Google Scholar
  16. 16.
    Cala LA, Jones B, Mastaglia FL, et al: Brain atrophy and intellectual impairment in heavy drinkers—A clinical psychometric and computed tomography study. Aust NZ J Med 8: 147–153, 1978CrossRefGoogle Scholar
  17. 17.
    Lusins J, Zimberg S, Smokier H, et al: Alcoholism and cerebral atrophy: A study of 50 patients with CT scan and psychologie testing. Alcoholism: Clin Exp Res 4: 406–411, 1980CrossRefGoogle Scholar
  18. 18.
    Ishii T: A comparison of cerebral atrophy in CT scan findings among alcoholic groups. Acta Psychiatr Scand 68: 7–30, 1983CrossRefGoogle Scholar
  19. 19.
    Bergman H, Borg S, Hindmarsh T, et al: Computed tomography of the brain and neuropsychological assessment on alcoholic patients. Adv Med Biol 126: 771–786, 1980Google Scholar
  20. 20.
    Lishman WA, Ron M, Acker W: Computed tomography of the brain and psychometric assessment of alcoholic patients—A British study, in Richter D (ed): Addiction and Brain Damage. London, Croom Helm, 1980, pp 215–227Google Scholar
  21. 21.
    Carlen PL, Wortzman G, Holgate R, et al: Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scan. Science 200: 1076–1078, 1978PubMedCrossRefGoogle Scholar
  22. 22.
    Carlen PL, Wilkinson DA, Wortzman G, et al: Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. Neurology (NY) 31: 377–385, 1981Google Scholar
  23. 23.
    Begleiter H, Projesz B: Neuroradiological and neurophysiological evidence of brain deficits in chronic alcholics. Acta Psychiatr Scand 62 (Suppl 186): 3–13, 1980CrossRefGoogle Scholar
  24. 24.
    Hill SY, Mikhael MA: Computerized transaxial tomography (CTT) and neuropsychological evaluations in chronic alcoholics and heroin addicts. Am J Psychiatry 136: 598–602, 1979Google Scholar
  25. 25.
    Golden CJ, Graber B, Blose I, et al: Difference in brain densities between chronic alcoholic and normal control patients. Science 211: 508–510, 1980CrossRefGoogle Scholar
  26. 26.
    Penn ED, Berlanger MD, Yasnoff WA: Ventricular volume in man computed from CAT scans. Ann Neurol 3: 216–223, 1978PubMedCrossRefGoogle Scholar
  27. 27.
    Naeser MA, Hayward RW, Laughlin SA, et al: Quantitative CT scan studies in aphasia I. Infarct size and CT numbers. Brain Lang 12: 140–164, 1981PubMedCrossRefGoogle Scholar
  28. 28.
    Naeser MA, Hayward RW, Laughlin SA, et al: Quantitative CT scan studies in aphasia II. Comparison of the right and left hemispheres. Brain Lang 12: 165–189, 1981PubMedCrossRefGoogle Scholar
  29. 29.
    Naeser MA, Gebhart C, Levine HL: Decreased computerized tomography numbers in patients with presenile dementia. Arch Neurol 37: 401–409, 1980PubMedCrossRefGoogle Scholar
  30. 30.
    Bondareff W, Baldy R, Levy R: Quantitative computed tomography in senile dementia. Arch Gen Psychiatry 38: 1365–1368, 1981PubMedCrossRefGoogle Scholar
  31. 31.
    Epstein PE, Pisani VD, Fawcett JA: Alcoholism and cerebral atrophy. Alcoholism 1: 61–65, 1977PubMedGoogle Scholar
  32. 32.
    Zelazowski R, Golden CJ, Graber B, et al: Relationship of cerebral ventricular size to alcoholics’ performance on the Luria–Nebraska neuropsychological battery. J Stud Alcohol 42: 749–756, 1981PubMedGoogle Scholar
  33. 33.
    Kroll P, Seigel R, O’Neill B, et al: Cerebral cortical atrophy in alcoholic men. J Clin Psychiatry 41: 417–421, 1980PubMedGoogle Scholar
  34. 34.
    Lee K, Moller L, Hardt F, et al: Alcohol-induced brain damage and liver damage in young males. Lancet 2: 759–761, 1979PubMedCrossRefGoogle Scholar
  35. 35.
    Haubek A, Lee K: Computed tomography in alcoholic cerebellar atrophy. Neuroradiology 19: 77–79, 1979CrossRefGoogle Scholar
  36. 36.
    Wilkinson DA, Carlen PL: Chronic organic brain syndromes associated with alcoholism: Neuropsychological and other aspects, in Israel Y, Glaser FB, Kalant H, et al (eds): Research Advances in Alcohol and Drug Problems, Vol 6. New York, Plenum Press, 1981, pp 107–145CrossRefGoogle Scholar
  37. 37.
    Bakan P: Left-handedness and alcoholism. Percept Mot Skills 36: 514, 1973PubMedCrossRefGoogle Scholar
  38. 38.
    Lee-Feldstein A, Harburg E: Alcohol use among right-and left-handed persons in a small community. J Stud Alcohol 43:824–829, 1982Google Scholar
  39. 39.
    Tarter R, McBride H, Buonpane N: Differentiation of alcoholics according to childhood history of minimal brain dysfunction, family history and drinking pattern. Arch Gen Psychiatry 34: 761–768, 1977PubMedCrossRefGoogle Scholar
  40. 40.
    Tarter RE, Schneider DU: Models and theories of alcoholism, in Tarter RE, Sugerman AA (eds): Alcoholism: Interdisciplinary Approaches to an Enduring Problem. Reading, Massachusetts, Addison-Wesley, 1976, pp 75–106Google Scholar
  41. 41.
    Tarter RE, Alterman A: Neuropsychological deficits in alcoholics: Etiological considerations. J Stud Alcohol 45: 1–9, 1984PubMedGoogle Scholar
  42. 42.
    Tarter RE, Alterman AI, Edwards KL: Neurobehavioral theory of alcoholism etiology, in Chaudron CD, Wilkinson DA (eds): Theories of Alcoholism. Toronto, Addiction Research Foundation, in press.Google Scholar
  43. 43.
    Tumarkin B, Wilson J, Snyder G: Cerebral atrophy due to alcoholism in young adults. US Armed Forces Med J 6: 67, 1955Google Scholar
  44. 44.
    Haug JO: Pneumoencephalographic evidence of brain damage in chronic alcoholics. Acta Psychiatr Scand 203: 135–143, 1968CrossRefGoogle Scholar
  45. 45.
    Brewer C, Perrett L: Brain damage due to alcohol consumption: An airencephalographic, psychometric and electroencephalographic study. Br J Addict 66: 170–182, 1971CrossRefGoogle Scholar
  46. 46.
    Carlsson C, Claeson LE, Karlsson KI, et al: Clinical, psychometric and radiological signs of brain damage in chronic alcoholism. Acta Neurol Scand 50: 85–92, 1979Google Scholar
  47. 47.
    Lee SH, Altamarino LS, Toglia JU: Cerebellar atrophy: Pneumoencephalography and computerized tomography correlation. Neuroradiology 16: 179–180, 1978PubMedCrossRefGoogle Scholar
  48. 48.
    Le May M, Abramowicz A: The pneumoencephalographic findings in various forms of cerebellar degeneration. Radiology 85: 284–290, 1965Google Scholar
  49. 49.
    Ferrer S, Santibanez T, Castro M, et al: Permanent neurological complications of alcoholism, in Popham RE (ed): Alcohol and Alcoholism. Toronto, University of Toronto, 1969, pp 264–274Google Scholar
  50. 50.
    Ferrer S: Complicaciones Neurologicas Cronicas del Alcoholismo. Santiago, Chile, Editorial Universitaria, 1970Google Scholar
  51. 51.
    Ron MA: The alcoholic brain: CT scan and psychological findings. Psychological Medicine, Monograph Supplement 3, Cambridge, Cambridge University Press, 1983Google Scholar
  52. 52.
    Fox JH, Ramsey RG, Auckman MS, et al: Cerebral ventricular enlargement: Chronic alcoholics examined by computerized tomography. JAMA 236: 365–368, 1976PubMedCrossRefGoogle Scholar
  53. 53.
    Huckman MS, Fox J, Topel J: The validity of criteria for the evaluation of cerebral atrophy by computer tomography. Neuroradiology 116: 85–92, 1975Google Scholar
  54. 54.
    von Gall M, Becker H, Artmann H, et al: Results of computer tomography on chronic alcoholics. Neuroradiology 16: 329–33I, 1978CrossRefGoogle Scholar
  55. 55.
    Wilkinson DA: Accelerated mental aging in alcoholism: working hypothesis or uncontrolled variable?, in Wilkinson DA (ed): Cerebral Deficits in Alcoholism. Toronto, Addiction Research Foundation, 1979, pp 61–77Google Scholar
  56. 56.
    Wilkinson DA, Carlen PL: Morphological abnormalities in the brain of alcoholics: Relationship to age, psychological test scores and patient type, in Wood WG, Elias MF (eds): Alcoholism and Aging: Advances in Research. Boca Raton, Florida, CRC Press, 1982, pp 61–77Google Scholar
  57. 57.
    Heinz ER, Martinez J, Haenggeli A: Reversibility of cerebral atrophy in anorexia nervosa and Cushing’s syndrome. Am J Comput Assist Tomogr 1: 415–418, 1977CrossRefGoogle Scholar
  58. 58.
    Bergman H, Borg S, Hindmarsh T, et al: Computed tomography of the brain and neuropsychological assessment of male alcoholic patients, in Richter D (ed): Addiction and Brain Damage. London, Croom Helm, 1980, pp 201–213Google Scholar
  59. 59.
    Bergman H, Borg S, Hindmarsh T, et al: Computed tomography of the brain and neuropsychological assessment of male alcoholic patients and a random sample from the general male population. Acta Psychiatr Scand 62 (Suppl 286): 47–56, 1980CrossRefGoogle Scholar
  60. 60.
    Bergman H, Borg S, Hindmarsh T, et al: Computed tomography of the brain, clinical examination and neuropsychological assessment of a random sample of men from the general population. Acta Psychiatr Scand 62 (Suppl 286): 77–88, 1980CrossRefGoogle Scholar
  61. 61.
    Ron MA, Acker W, Lishman WA: Morphological abnormalities in the brains of chronic alcoholics—A clinical, psychological and computerized axial tomographic study. Acta Psychiatr Scand 62 (Suppl 286): 41–46, 1980CrossRefGoogle Scholar
  62. 62.
    Lishman WA, Ron M, Acker W: Computed tomography of the brain and psychometric assessment of alcoholic patients—A British study, in Sandler M (ed): Pharmacology of Alcohol. New York, Raven Press, 1980, pp 33–41Google Scholar
  63. 63.
    Wilkinson DA, Carlen PL: Neuropsychological and neurological assessment of alcoholism. Discrimination between groups of alcoholics. J Stud Alcohol 41: 129–139, 1980PubMedGoogle Scholar
  64. 64.
    Wilkinson DA, Carlen PL: Relation of neuropsychological test performance in alcoholics to brain morphology measured by computed tomography. Adv Exp Med Biol 126: 683–699, 1980PubMedGoogle Scholar
  65. 65.
    Wilkinson DA, Carlen PL: Relationship of neuropsychological test performance to brain morphology in amnesic and non-amnesic chronic alcoholics. Acta Psychiatr Scand 62 (Suppl 286): 89–101, 1980CrossRefGoogle Scholar
  66. 66.
    Carlen PL, Wilkinson DA: Alcoholic brain damage and reversible deficits. Acta Psychiatr Scand 62 (Suppl 286): 103–118, 1980CrossRefGoogle Scholar
  67. 67.
    Cala LA, Mastaglia FL: Computerized axial tomography in the detection of brain damage. Med J Aust 2: 193–198, 1980PubMedGoogle Scholar
  68. 68.
    Cala LA, Jones B, Wiley B, et a1: A computerized axial tomography (C.A.T.) study of alcohol induced cerebral atrophy—In conjunction with other correlates. Acta Psychiatr Scand 62 (Suppl 286): 31–40, 1980CrossRefGoogle Scholar
  69. 69.
    Agnoli AL, Tzavaras N, Reisig L: Computertomographische Befunde bei Alkoholismus. Fortschr Röntgenstr 132: 565–572, 1980CrossRefGoogle Scholar
  70. 70.
    Hill SY, Comprehensive assessment of brain dysfunction in alcoholic individuals. Acta Psychiatr Scand 62 (Suppl 286): 57–75, 1980CrossRefGoogle Scholar
  71. 71.
    Nahser HC, Ilsen HW, Lodemann E, et al: Clinical and CT investigation of chronic alcoholism (abstract). Neuroradiology 20: 272, 1980Google Scholar
  72. 72.
    Ron MA, Acker W, Shaw GK, et al: Computerized tomography of the brain in chronic alcoholism: A survey and follow-up study. Brain 105: 497–514, 1982PubMedCrossRefGoogle Scholar
  73. 73.
    Matthews CG, Booker HE: Pneumoencephalographic measurements and neuropsychological test performance in human adults. Cortex 8: 69–92, 1972PubMedGoogle Scholar
  74. 74.
    McFie J: Psychological testing in clinical neurology. J Nery Ment Dis 131: 383–393, 1960CrossRefGoogle Scholar
  75. 75.
    livanainen M: Statistical correlations of diffuse cerebral atrophy with special reference to diagnostic and etiological clues. Acta Neurol Scand 51: 365–379, 1975CrossRefGoogle Scholar
  76. 76.
    Ryan C, Butters N: Further evidence for a continuum-of-impairment encompassing male alcoholic Korsakoff patients and chronic alcoholic men. Alcoholism: Clin Exp Res 4: 190–198, 1980CrossRefGoogle Scholar
  77. 77.
    Tarter RE: Psychological deficit in chronic alcoholics: A review. Intl Addict 10: 327–368, 1975Google Scholar
  78. 78.
    Parsons OA, Farr SP: The neuropsychology of alcohol and drug use, in Filskov S, Boll T (eds): Handbook of Clinical Neurop.tiychology. New York, Wiley, 1981, pp 320–365Google Scholar
  79. 79.
    Miller WR, Saucedo CF: Assessment of neuropsychological impairment and brain damage in problem drinkers, in Golden CJ, Moses JA Jr, Coffman JA, et al (eds): Clinical Neuropsychology: Interface with Neurologic and Psychiatric Disorders. New York, Grune and Stratton, 1983, pp 141–271Google Scholar
  80. 80.
    Reitan RM, Davison LA: Clinical Neuropsychologs’: Current Status and Applications. New York, Winston—Wiley, 1974Google Scholar
  81. 81.
    Russell EW, Neuringer C. Goldstein G (eds): Assessment of Brain Damage. New York, Wiley, 1970Google Scholar
  82. 82.
    Matarazzo JD (ed): Wechsler’s Measurement and Appraisal of Adult Intelligence, ed 5. Baltimore, Williams and Wilkins Co, 1972Google Scholar
  83. 83.
    Chmielewski C, Golden CJ: Alcoholism and brain damage: An investigation using the Luria—Nebraska neuropsychological battery. Int J Neurosci 10: 99–105, 1980PubMedCrossRefGoogle Scholar
  84. 84.
    Dublin AB, Dublin WB: Cerebral pseudoatrophy and computed tomography: Two illustrative case reports. Surg Neurol 10: 209–212, 1978PubMedGoogle Scholar
  85. 85.
    Bentson J, Reza M, Winter V, et al: Steroids and apparent cerebral atrophy on computed tomographic scans. J Comput Assist Tomogr 2: 16–23, 1978PubMedCrossRefGoogle Scholar
  86. 86.
    Ledesma JA: Estudios pneumoencefalograficos en el alcoholismo. Rev Clin Esp 68: 161–171, 1958Google Scholar
  87. 87.
    Artmann H, von Gall M, Hacker H, et al: Reversible enlargement of cerebral spinal fluid spaces in chronic alcoholics. Am J Neuroradiol 2: 23–27, 1981PubMedGoogle Scholar
  88. 88.
    Sarabia F, Bowden CL, Tex SA: Computerized tomographic evidence of cerebral atrophy in heavy drinkers. South Med J 73: 716–718, 1980PubMedCrossRefGoogle Scholar
  89. 89.
    Cala LA, Jones B, Burns P, et al: Results of computerized tomography, psychometric testing and dietary studies in social drinkers, with emphasis on reversibility after abstinence. Med J Aust 60: 264–269, 1973Google Scholar
  90. 90.
    Carlen PL, Wilkinson DA, Wortzman G, et al: Partially reversible cerebral atrophy and functional improvement in recently abstinent alcoholics. Can J Neurol Sci 11: 441–446, 1983Google Scholar
  91. 91.
    Carlen PL: Computed tomography scans of alcoholics: Cerebral atrophy? Science 204: 1238, 1979PubMedCrossRefGoogle Scholar
  92. 92.
    Carlen PL: Reversible effects of chronic alcoholism on the human central nervous system: possible eiological mechanisms, in Wilkinson DA (ed): Cerebral Deficits in Alcoholism. Toronto, Addiction Research Foundation, 1979, pp 107–122Google Scholar
  93. 93.
    Walker DW, Hunter BE, Barnes DE, et al: An animal model of alcohol-induced brain damage: Behavioral and anatomical analysis, in Wilkinson DA (ed): Cerebral Deficits in Alcoholism. Toronto, Addiction Research Foundation, 1979, pp 123–147Google Scholar
  94. 94.
    Acker W, Aps EJ, Majumdar SK, et al: The relationship between brain and liver damage in chronic alcoholic patients. J Neural Neurosurg Psychiatry 45: 984–987, 1982CrossRefGoogle Scholar
  95. 95.
    Gebhardt CA: Computer analysis of CT scans of chronic alcoholics: The relation of third ventricle region to memory and frontal/parietal regions to perception. Ph.D. Thesis, Boston University, Boston, Massachusetts, 1981Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • D. Adrian Wilkinson
    • 1
  1. 1.Addiction Research FoundationTorontoCanada

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