Chemistry of Collagen Crosslinking: Relationship to Aging and Nutrition

  • Philip E. McClain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 86)


Collagen is a major constituent of skin, bone, tendon, and cartilage and is a vital component of the cardiovascular system. Not only is collagen an important protein because of its relative abundance, estimates indicate that it constitutes as much as 40% of the total body protein, but also it is the only protein in the body that has been clearly shown to undergo molecular changes during the aging process in man and animals, i. e., it “ages.” One of the outward manifestations of aging in collagen is the wrinkling of the skin which is inevitable in the elderly. Another, which is not so obvious but is of infinitely greater importance to man is the age-associated loss of elasticity in the cardiovascular system.


Zinc Proline Fructose Apatite Tritium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Wertheim, M. G., Ann. Chim. et Phys. 21, 385 (1847).Google Scholar
  2. 2.
    Rollhäuser, H., Gegenbaurs Morph. Jb. 90, 157 (1950).Google Scholar
  3. 3.
    Mendoza, S. A. and Milch, R. A., Gerontologia 10, 42 (1964).PubMedCrossRefGoogle Scholar
  4. 4.
    Nimni, M. E., DeGuia, E. and Baretta, L. A., Nature 207, 865 (1965).PubMedCrossRefGoogle Scholar
  5. 5.
    Verzar, F., Experientia 11, 230 (1955).Google Scholar
  6. 6.
    McClain, P. E., Pearson, A. M., Miller, E. R. and Dugan, L. R., Biochem. Biophys. Acta 168, 143 (1968).CrossRefGoogle Scholar
  7. 7.
    Brown, P. C. and Consden, R., Nature 181, 349 (1958).PubMedCrossRefGoogle Scholar
  8. 8.
    Schaub, M. C., Gerontologia 8, 114 (1963).CrossRefGoogle Scholar
  9. 9.
    Verzar, F., Gerontologia 4, 105 (1960).Google Scholar
  10. 10.
    McClain, P. E., Proc. 29th Ann. Rec. Meat Conf. In Press (1976).Google Scholar
  11. 11.
    McClain, P. E., Kuntz, E. and Pearson, A. M., Agr. and Food Chem. 17, 629 (1969).CrossRefGoogle Scholar
  12. 12.
    Shimokamaki, M., Elsden, D. F. and Bailey, A. J., J. Food Sci. 37, 892 (1972).CrossRefGoogle Scholar
  13. 13.
    Bailey, A. J., Robins, S. P. and Balian, G., Nature, 251, 105 (1974).PubMedCrossRefGoogle Scholar
  14. 14.
    Prockop, D., Kaplan, A. and Undenfriend, S., Arch. Biochem. Biophys. 101, 499 (1963).PubMedCrossRefGoogle Scholar
  15. 15.
    Rhoads, R. E. and Undenfriend, S., Proc. Natl. Acad. Sci. U. S. 60, 1473 (1968).Google Scholar
  16. 16.
    Bhatnagar, R. S., Rapaka, S. R., Liu, R. Z. and Wolfe, S. M., Biochim. Biophys. Acta 271, 125 (1972).CrossRefGoogle Scholar
  17. 17.
    Hayaishi, 0., In: Biological Oxidations Ed. T. P. Singer, New York, Interscience P. 581 (1968).Google Scholar
  18. 18.
    Hutton, J J., Jr., Tappel, A. L. and Undenfriend, S., Arch. Biochem. Biophys. 118, 231 (1967).CrossRefGoogle Scholar
  19. 19.
    Stassen, F. L. H., Gardinale, G. J. and Unden Friend, S., Proc. Natl. Acad. Sci. U. S., 70, 1090 (1973).CrossRefGoogle Scholar
  20. 20.
    Berg, R. A. and Prockop, D. J., Biochem. Biophys. Res. Commun., 52, 115 (1973).CrossRefGoogle Scholar
  21. 21.
    Jimenez, S., Harsch, M. and Rosenbloom, J., Biochem. Biophys. Res. Commun., 52, 106 (1973).CrossRefGoogle Scholar
  22. 22.
    Toole, B. P., Kang, A. H., Trelstad, R. L. and Gross, J., Biochem. J. 127, 715 (1972).PubMedGoogle Scholar
  23. 23.
    Barnes, M. J., Constable, B. J., Morton, L. F. and Kodicek, E., Biochem. J. 132, 113 (1973).PubMedGoogle Scholar
  24. 24.
    Mechanic, G. L., Toverud, S. V. and Ramp, W. K. Biochem. Biophys. Res. Commun. 47, 760 (1972).Google Scholar
  25. 25.
    Asling, C. W. and Hurley, L. S., Clin. Orthoped. 23, 213 (1963).Google Scholar
  26. 26.
    Shields, G. S., Coulson, W. F., Kimball, D. A., Carnes, W. H., Cartwright, G. E. and Wintrobe, M. M., Am. J. Pathol. 41, 603 (1962).PubMedGoogle Scholar
  27. 27.
    O’Dell, B. L., Hardwick, B. C., Reynold, G. and Savage, J. E., Proc. Soc. Exptl. Biol. Med., 108, 402 (1961).CrossRefGoogle Scholar
  28. 28.
    Chou, W. S., Savage, J. E. and O’Dell, B. L., Proc. Soc. Exp. Biol. Med., 128, 948 (1968).CrossRefGoogle Scholar
  29. 29.
    Harris, E. D. and O’Dell, B. L., Adv. in Exp. Med. and Biol. 48, 267 (1974).Google Scholar
  30. 30.
    Savage, J. E., Bird, D. W., Reynolds, G. and O’Dell, B. L. J. Nutr. 88, 15 (1966).PubMedGoogle Scholar
  31. 31.
    Todd, W. R., Elvejhem, C. A. and Hart, H. B., Am. J. Physiol. 107, 146 (1934).Google Scholar
  32. 32.
    Pories, W. J., Henzel, J. H., Rob, C. G. and Strain, W. H., Lancet 1, 121 (1967).PubMedCrossRefGoogle Scholar
  33. 33.
    McClain, P. E., Wiley, E. R., Beecher, G. R., Anthony, W. L. and Hsu, J. M., Biochem. Biophys. Acta 304, 457 (1973).CrossRefGoogle Scholar
  34. 34.
    Pories, W. J., Henzel, J. H., Rob, C. G. and Strain, W. H., Ann. Surg. 165, 432 (1967).PubMedCrossRefGoogle Scholar
  35. 35.
    McKay, C. M., Amer. J. Publ. Hlth. 37, 521 (1947).CrossRefGoogle Scholar
  36. 36.
    Chvapil, M. and Hruza, Z., Gerontologia 3, 241 (1959).PubMedCrossRefGoogle Scholar
  37. 37.
    Deyl, Z. and Rosmus, J., Exp. Geront. 3, 177 (1968).CrossRefGoogle Scholar
  38. 38.
    Prasad, C. U. and Bose, S. M., Nutr. Metabol. 16, 172 (1974).CrossRefGoogle Scholar
  39. 39.
    McClain, P. E., Wiley, E. R. and Beecher, G. R., Nutr. Rep. Int. 12, 317 (1975).Google Scholar
  40. 40.
    McClain, P. E. and Wiley, E. R. Fed. Proc. 30, 402A (1971).Google Scholar
  41. 41.
    Beisswenger, P. J. and Spiro, R. G. Science, 168, 596 (1970).CrossRefGoogle Scholar
  42. 42.
    Sinex, F. M., In: Treatise on Collagen Ed. B. S. Gould. New York: Academic Press p. 409 (1968).Google Scholar

Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Philip E. McClain
    • 1
  1. 1.U. S. Department of AgricultureAgricultural Research Service, Nutrition InstituteBeltsvilleUSA

Personalised recommendations