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Advances in Psychoneuroimmunology pp 83–98Cite as

Immunomodulation by Growth Hormone in Humans

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Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HSSN,volume 3))

Abstract

The role of growth hormone in the establishment and maintenance of the immune system of animals has been well documented. Beginning with the demonstration of involution of the thymus gland following hypophysectomy,1 many studies have shown diminished immune functions in hypophysectomized animals that were reversible by growth hormone administration.2–8 Growth hormone has also been reported to stimulate DNA synthesis and c-myc proto-oncogene expression9 as well as superoxide anion production10,11 in hypophysectomized rats.

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  1. Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Children’s Hospital of New Jersey UMD-New Jersey Medical School, 15 South 9th Street, Newark, NJ, 07107, USA

    Robert Rapaport

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  1. Department of Immunology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Istvan Berczi

  2. National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary

    Judith Szélenyi

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Rapaport, R. (1994). Immunomodulation by Growth Hormone in Humans. In: Berczi, I., Szélenyi, J. (eds) Advances in Psychoneuroimmunology. Hans Selye Symposia on Neuroendocrinology and Stress, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9104-4_6

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