Neuroendocrine Control of the Thymic Microenvironment: Role of Pituitary Hormones

  • Wilson Savino
  • Valeria Mello-Coelho
  • Mireille Dardenne
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


Within the well demonstrated immunoneuroendocrine network, the nervous, endocrine and immune systems communicate through common mediators and respective receptors, working in fine harmony, they contribute to homeostasis.1


Growth Hormone Thymic Epithelial Cell Prolactin Receptor Dwarf Mouse Thymic Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J.E. Blalock, Neuroimmunoendocrinology, Chem. Immunol. 52:1 (1992).PubMedCrossRefGoogle Scholar
  2. 2.
    R. Ader, D. L. Feiten and N. Cohen, “Psychoneuroimmunology,” Academic Press, San Diego, CA (1991).Google Scholar
  3. 3.
    M. Dardenne and W. Savino, Neuroendocrine control of thymic epithelium: Modulation of thymic endocrine function, cytokeratin expression and cell proliferation by hormones and neuropeptides, Prog. NeuroEndocrinlmmunol. 3:18 (1990).Google Scholar
  4. 4.
    M. Dardenne and W. Savino, Neuroendocrine circuits controlling the physiology of the thymic epithelium, Ann. N.Y. Acad. Sci. 650:85 (1992).PubMedCrossRefGoogle Scholar
  5. 5.
    W. Van Ewijk, T-cell differentiation is influenced by thymic microenvironments, Ann. Rev. Immunol. 9:591 (1991).CrossRefGoogle Scholar
  6. 6.
    J.F. Bach, Thymic hormones, Clin. Immunol. Allergy 3:133 (1983).Google Scholar
  7. 7.
    P.T. Le, D.T. Tuck, C.A. Dinarello, B.F. Haynes and K.H. Singer, Thymic epithelial cells produce interleukin 1, J. Immunol. 138:2520 (1988).Google Scholar
  8. 8.
    P.T. Le, S. Lazorich, L.P. Whichard, Y.C. Yang, S.C. Clarck, B.F. Haynes and K.H. Singer, Human thymic epithelial cells produce IL-6, granulocyte-monocyte CSF and leukemia inhibitory factor, J. Immunol. 145:3310 (1990).PubMedGoogle Scholar
  9. 9.
    P.T. Le, J. Kurtzberg, S.L. Brant, J.E. Nieldel, B.H. Haynes and K.H. Singer, Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors, J. Immunol. 141:1211 (1988).PubMedGoogle Scholar
  10. 10.
    S. Nonayama, M. Nakayama, T. Shiohara and J. Yata, Only dull CD3+ thymocytes bind to thymic epithelial cells. The binding is elicited by both CD2/LFA-3 and LFA-l/ICAM-1 interactions, Eur. J. Immunol. 19:1631 (1989).CrossRefGoogle Scholar
  11. 11.
    G. Janossy, J.A. Thomas, F.L. Bollum, G. Granzer, G. Pizzolo, K.F. Bradstock, L. Wong, K. Ganeshagun and A.B. Hoffbrand, The human thymic microenvironment: an immunohistologic study, J. Immunol. 125:202 (1980).PubMedGoogle Scholar
  12. 12.
    E.J. Jenkinson, W. Van Ewijk and J.J. Owen, Major histocompatibility complex antigen expression on the epithelium of developing thymus in normal and nude mice, J. Exp. Med. 153:280 (1981).PubMedCrossRefGoogle Scholar
  13. 13.
    W. Savino, G. Manganella, J.M. Verley, A. Wolff, S. Berrih, P. Levasseur, J.P.Binet, M. Dardenne and J.F. Bach, Thymoma epithelial cells secrete thymic hormone but do not express class II antigens of the major histocompatibility complex, J. Clin. Invest. 76:1140 (1985).PubMedCrossRefGoogle Scholar
  14. 14.
    W. Van Ewijk, Y. Ron, J. Monaco, J. Kapplier, P. Marrack, H. Le Meur, P. Gerlinger, B. Durand, C. Benoist and D. Mattis, Compartimentalization of MHC class II gene expression in transgenic mice, Cell 53:357 (1988).PubMedCrossRefGoogle Scholar
  15. 15.
    W. Savino and J. Lannes-Vieira, Is there a function for extracellular matrix in thymus physiology and pathology? Mem. Inst. Oswaldo Cruz 85:90 (1991).Google Scholar
  16. 16.
    J.F. Bach, M. Dardenne, J.M. Pleau and J. Rosa, Biochemical characterization of a serum thymic hormone, Nature 266:55 (1977).PubMedCrossRefGoogle Scholar
  17. 17.
    W. Savino, M. Dardenne, M. Papiernik and J.F. Bach, Thymic hormone containing cells. Characterization of serum thymic factor in young mouse thymus studied by monoclonal antibodies, J. Exp. Med. 156:628 (1982).PubMedCrossRefGoogle Scholar
  18. 18.
    N. Fabris and E. Mocchegiani, Endocrine control of serum thymic factor in young-adult and old mice, Cell. Immunol. 91:325 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    N. Fabris, E. Mocchegiani, S. Mariotti, F. Pacini and A. Pinchera, Thyroid function modulates thymic endocrine activity, J. Clin. Endocrin. Metab. 62:474 (1986).CrossRefGoogle Scholar
  20. 20.
    W. Savino, E. Bartoccioni, F. Homo-Delarche, M.C. Gagnerault, T. Itoh and M. Dardenne, Thymic hormone containing cells — IX. Steroids in vitro modulate thymulin secretion by human and murine thymic epithelial cells, J. Steroid Biochem. 19:135 (1988).Google Scholar
  21. 21.
    J. Lannes-Vieira, M. Dardenne and W. Savino, Extracellular matrix components of the mouse thymus microenvironment: ontogenetic studies and modulation by glucocorticoid hormones, J. Histochem. Cytochem. 39:113 (1991).CrossRefGoogle Scholar
  22. 22.
    W. Savino, E.O. Cirne-Lima, J.F.T. Soares, M.C. Leite de Moraes, I.P.C. Ono and M. Dardenne, Hydrocortisone increases the number of KL1+ cells, a discrete thymic epithelial cell subset characterized by high molecular weight cytokeratin expression, Endocrinology 123:2557 (1988).PubMedCrossRefGoogle Scholar
  23. 23.
    W. Savino, E. Ban, D.M. Villa-Verde and M. Dardenne, Modulation of thymic endocrine function, cytokeratin expression and cell proliferation, by hormones and neuropeptides, Int. J. Neurosa. 51:201 (1990).CrossRefGoogle Scholar
  24. 24.
    J. Larmes-Vieira, P.H. Van Der Meide and W. Savino, Extracellular matrix components of the mouse thymus microenvironment. II. Gamma-interferon modulates thymic epithelial cell proliferation and extracellular matrix production, Cell. Immunol. 137:329 (1991).CrossRefGoogle Scholar
  25. 25.
    M. Dardenne, T. Itoh and F. Homo-Delarche, Presence of glucocorticoid receptors in cultured thymic epithelial cells, Cell. Immunol. 100:112 (1986).PubMedCrossRefGoogle Scholar
  26. 26.
    D.M. Villa-Verde, M.P. Defresne, M.A. Vannier-dos-Santos, J.H. Dussault, J. Boniver and W. Savino, Identification of nuclear trioiodothyronine receptors in the thymic epithelium, Endocrinology 131:1313 (1992).PubMedCrossRefGoogle Scholar
  27. 27.
    C. Baroni, Thymus, peripheral lymphoid tissues, and immunological responsiveness of the pituitary dwarf mouse, Experientia 23:282 (1967).PubMedCrossRefGoogle Scholar
  28. 28.
    N. Fabris, W. Pierpaoli and E. Sorkin, Hormones and the immunological activity. IV. Restorative effects of developmental hormones on lymphocytes of the immunodeficiency syndrome of the dwarf mouse, Clin. Exp. Immunol. 9:227 (1971).PubMedGoogle Scholar
  29. 29.
    M. Pelletier, S. Montplaisir, M. Dardenne and J.F. Bach, Thymic hormone activity and spontaneous autoimmunity in dwarf mice and their littermates, Immunology 30:783 (1976).PubMedGoogle Scholar
  30. 30.
    B.L. Goff, J.A. Roth, L.H. Arp and G.S. Incefy, Growth hormone treatment stimulates thymulin production in aged dogs, Clin. Exp. Immunol. 68:580 (1987).PubMedGoogle Scholar
  31. 31.
    R.G. Goya, M.C. Gagnerault, M.C. Leite de Moraes, W. Savino and M. Dardenne, In vivo effects of growth hormone on thymus function in aging mice, Brain Behav. Immun. 6:341 (1992).PubMedCrossRefGoogle Scholar
  32. 32.
    K.W. Kelley, S. Brief, H.J. Weatly, J. Novakofski, P.J. Bechtel, J. Simon and E.B. Walker, GH3 pituitary adenoma cells can reverse thymic aging in rats, Proc. Natl. Acad. Sci. USA 83:5663 (1986).PubMedCrossRefGoogle Scholar
  33. 33.
    M. Dardenne, W. Savino, M.C. Gagnerault, T. Itoh and J.F. Bach, Neuroendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells, Endocrinology 125:1251 (1989).CrossRefGoogle Scholar
  34. 34.
    J. Timsit, W. Savino, W. Safieh, P. Chanson, M.C. Gagnerault, J.F. Bach and M. Dardenne, Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells, J. Clin. Endocrin. Metab. 75:183 (1992).CrossRefGoogle Scholar
  35. 35.
    E. Ban, M.C. Gagnerault, H. James, M.C. Postei-Vinay, F. Haour and M. Dardenne, Specific binding sites for growth hormone in cultured mouse thymic epithelial cells, Life Sci. 48:2141 (1991).PubMedCrossRefGoogle Scholar
  36. 36.
    D.H. Russell, R. Kibler, L. Matrisian, D.F. Larson, B. Poulos and B.E. Magun, Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine, J. Immunol. 134:3027 (1985).PubMedGoogle Scholar
  37. 37.
    M. Dardenne, P.A. Kelly, J.F. Bach and W. Savino, Identification and functional activity of prolactin receptors in thymic epithelial cells, Proc. Natl. Acad. Sci. USA 88:9700 (1991).PubMedCrossRefGoogle Scholar
  38. 38.
    M.C. Gagnerault, P. Touraine, W. Savino, P.A. Kelly and M. Dardenne, Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations, J. Immunol. 150:5673 (1993).PubMedGoogle Scholar
  39. 39.
    M. Dardenne, M. C. Leite de Moraes, P. A. Kelly and M. C. Gagnerault, Prolactin receptor expression in human hematopoietic tissues analysed by flow cytofluorometry, Endocrinology (1994) (in press).Google Scholar
  40. 40.
    Pellegrini, J.J. Lebrun, S. Ali and P.A. Kelly, Expression of prolactin and its receptor in human lymphoid cells, Mol. Endocrinol. 6:1023 (1992).PubMedCrossRefGoogle Scholar
  41. 41.
    I. Screpanti, D. Meco, S. Morrone, A. Gulino, B.J. Mathielson and L. Frati, In vivo modulation of the distribution of thymocyte subsets: effects of estrogen on the expression of different T cell receptor Vβ gene families in CD4CD8’ thymocytes, Cell Immunol. 134:414 (1991).PubMedCrossRefGoogle Scholar
  42. 42.
    V. Geenen, H. Martens, F. Robert, J.J. Legros, M.P. Defresne, J. Boniver, J. Martial, P.J. Lefebvre and P. Franchimont, Thymic cryptocrine signalling and the immune recognition of self neuroendocrine function, Prog. NeuroEndocrinelmmunol 4:135 (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Wilson Savino
  • Valeria Mello-Coelho
    • 1
  • Mireille Dardenne
    • 2
  1. 1.Department of ImmunologyThe Oswaldo Cruz FoundationManguinhosBrazil
  2. 2.Hopital NeckerCNRS URAParisFrance

Personalised recommendations