Plasticity of Neuroendocrine-Immune Interactions During Aging

  • N. Fabris
  • E. Mocchegiani
  • M. Provinciali
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


A good body of experimental evidences now supports the existence of numerous interactions among the nervous, endocrine and immune systems. Communication between these networks is mediated by humoral mediators, such as hormones, neurotransmitters and immune-derived cytokines, which are to a large extent shared by the different homeostatic systems. Common to nervous, neuroendocrine and immune cells are also the receptor sites sensitive to such signals. Hormones and neurotransmitters, in addition to regulating various target tissues in the body, reach also lymphoid organs and cells through blood circulation or through direct autonomic-nervous-system (ANS) connections between the nervous tissue and the organs of the lymphoid system itself (for review see1,2). The neuro-endocrine-immune interactions supported by circulating humoral mediators are mainly due to and mediated by the hypothalamus-pituitary axis; this may influence the immune system either releasing by various hormones and neuropeptides into the blood with direct modulatory action on the immune effectors, or regulating the hormonal secretion of peripheral endocrine glands, which also exert an immuno-modulating action.


Growth Hormone Natural Killer Activity Zinc Salt Homeostatic System Thymic Endocrine 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • N. Fabris
    • 1
    • 2
  • E. Mocchegiani
    • 1
  • M. Provinciali
    • 1
  1. 1.Immunology Center, Gerontological Research DepartmentItalian Natl. Res. Ctrs. on Aging (INRCA)AnconaItaly
  2. 2.Inst. of Haematology, Medical FacultyUniversity of PaviaItaly

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