Mechanisms of Stress-Induced Host Defense Alterations

  • Alex Kusnecov
  • Bruce S. Rabin
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


The initial processing and subsequent physiological response to an aversive situation or environmental cues previously associated with an aversive situation (conditioned stimuli) occurs within the brain. Using experimental models, many of the areas of the brain which respond to a stressor have been identified. The role of neurohormones within the brain and the participation of the sympathetic nervous system in altering immune function is also beginning to be clarified. The primary interest of our research laboratory is to understand the mechanisms which are activated after a subject experiences a stressor and the resultant alteration of immune system function.


Natural Killer Cell Conditioned Stimulus Sympathetic Nervous System Peripheral Blood Lymphocyte Locus Coeruleus 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Alex Kusnecov
    • 1
  • Bruce S. Rabin
    • 1
  1. 1.The Brain, Behavior, and Immunity Center and the Department of PathologyThe University of Pittsburgh School of MedicinePittsburghUSA

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