Neuroendocrine Aspects of Lymphocyte Migration

  • C. A. Ottaway
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


Lymphocyte migration plays a central role in adaptive responses because it permits the continuous redeployment of specialist lymphocytes between different compartments of the body. Through this process, the immune system undergoes dynamic remodelling in response to physiological and antigenic challenges. There have been rapid advances in our understanding of the cellular and molecular features that contribute to migration of lymphocytes in vivo, which are well reviewed elsewhere.1,2 It is now traditional to consider the first step in lymphoid migratory behaviour to be the exit of the cells from the blood stream. In lymph nodes, Peyer’s patches and virtually all other tissues of the body with the exception of the spleen, lymphocytes leave the cardiovascular system via the postcapillary venules (PCV),3 and the attachment of migrating lymphocytes to the endothelium depends upon the reciprocal interaction of adhesion molecules at the surface of these cells.4,5


Large Granular Lymphocyte Postcapillary Venule Lymphocyte Migration Sympathoadrenal Activation Splenic White Pulp 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • C. A. Ottaway
    • 1
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada

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