Expression of Cholinergic Structures on Lymphocytes

  • Judith Szelenyi
  • Nguyen Thi Hu Ha
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


A number of receptors, surface markers and enzymes are known to be expressed commonly on cells of nervous-, neuroendocrine- and immune-systems. The presence of cholinergic structures, i.e. muscarinic (mAChR) and nicotinic (nAChR) receptors as well as acetylcholinesterase (AChE) on peripheral blood lymphocytes (PBLs) was reported by several authors.1–4 As might be expected, lymphocytes respond to parasympathetic signals. mAChR agonists increase PBL motility and Chemotaxis,5,6 rosette formation7 and proliferation2 while unilateral parasympathectomy results in decreased plaque-forming cell response in submandibular lymph nodes.8 In vitro inhibition of AChE results in decreased T-cell rosette formation9 while the in vivo administration of physostigmine increases the number of plaque-forming cells.10


Peripheral Blood Lymphocyte AChE Activity Nicotinic Acetylcholine Receptor Senile Dementia Muscarinic Acetylcholine Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    T.B. Strom, A. Deisseroth, J. Morganroth, C.B. Carpenter, and J.P. Merrill, Alteration of cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase, Proc. Natl. Acad. Sci. 69:2995 (1972).PubMedCrossRefGoogle Scholar
  2. 2.
    D.P. Richman and B.G.W. Arnason, Nicotinic acetylcholine receptor: evidence for functionally distinct receptor on human lymphocytes, Proc. Natl. Acad. Sci. 76:4632 (1979).PubMedCrossRefGoogle Scholar
  3. 3.
    S.J. Zalcman, L.M. Neckers, O. Kayaalp, and R.J. Wyatt, Muscarinic cholinergic binding sites on intact human lymphocytes, Life Sci. 29:69 (1983).CrossRefGoogle Scholar
  4. 4.
    J.G. Szelenyi, E. Bartha, and S.R. Hollan, Acetylcholinesterase activity of lymphocytes: an enzyme characteristic of the T-cells, Brit. J. Haematol. 50:241 (1982).CrossRefGoogle Scholar
  5. 5.
    G.F. Schreiner and E.R. Unanue, The modulation of spontaneous and anti IgG stimulated motility of lymphocytes by cyclic nucleotides and adrenergic and cholinergic agents, J. Immunol. 114:802 (1975).PubMedGoogle Scholar
  6. 6.
    S. Sipka, P. Dioszeghy, F. Melcher, K. Lukacs, J. Szelenyi, and G. Szegedi, Decreases in the carbamoylcholine-induced Chemotaxis of monocytes in myasthenia gravis, Eur. Arch. Psychiatr. Clin. Neurosci. 240:279 (1991).CrossRefGoogle Scholar
  7. 7.
    M.H. Grieco, I. Siegel, and Z. Goel, Modulation of human T lymphocyte rosette formation by autonomic agonists and cyclic nucleotides, J. Allergy Clin. Immunol. 58:149 (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Alito, H.E. Romeo, R. Baler, H.E. Chuluyan, M. Braun, and D.P. Cardinali, Autonomic nervous system regulation of murine immune responses as assessed by local surgical sympathetic and parasympathetic dennervation, Acta Physiol. Pharmacol. Latinoam. 37:305 (1987).PubMedGoogle Scholar
  9. 9.
    R.K. Chandra and K. Madhavankutty, Effect of Cholinesterase inhibition by eserine and phospholipase D on human T-cell rosetting, Experientia 31:858 (1975).PubMedCrossRefGoogle Scholar
  10. 10.
    I. Rinner and K. Schauenstein, The parasympathetic nervous system takes part in the immuno-neuroendocrine dialogue, J. Neuroimmunol. 34:165 (1991).PubMedCrossRefGoogle Scholar
  11. 11.
    T.B. Strom, M.A. Lane, and K. George, The parallel, time-dependent bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte-mediated cytotoxicity after lymphocyte activation, J. Immunol 127:705 (1981).PubMedGoogle Scholar
  12. 12.
    W. Maslinski, E. Grabczewska, H. Laskowska-Bozek, and J. Ryzewski, Expression of muscarinic cholinergic receptors during T-cell maturaiton in the thymus, Eur. J. Immunol. 17:1059 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    P. Paldi-Haris and J. Szelenyi, Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation, Thymus 16:119 (1990).PubMedGoogle Scholar
  14. 14.
    W. Augener, G. Cohnen, A. Reuter, and G. Brittinger, Decrease of T lymphocytes during ageing, Lancet 1:1164 (1974).PubMedCrossRefGoogle Scholar
  15. 15.
    A. Ben-Zvi, U. Galili, A. Russel, and M. Schlesinger, Age associated changes in subpopulations of human lymphocytes, Clin. Immunol. Immunopathol. 7:139 (1977).CrossRefGoogle Scholar
  16. 16.
    J.M. Rabey, L. Schenkman, and G.M. Gilad, Cholinergic muscarinic binding by human lymphocytes: changes with ageing, antagonist treatment, and senile dementia of the Alzheimer type, Ann. Neurol. 20:628 (1986).PubMedCrossRefGoogle Scholar
  17. 17.
    A. Adem, A. Nordberg, G. Bucht, and B. Winblad, Extraneuronal cholinergic markers in Alzheimer’s and Parkinson’s disease, Prog. Neuro-Psychopharmacol. Biol. Psychiat. 10:247 (1986).CrossRefGoogle Scholar
  18. 18.
    L. Bonomo, S. Antonici, and E. Jiriollo, Cell mediated immune response in the elderly, Bull. Inst. Pasteur 81:347 (1983).Google Scholar
  19. 19.
    J.G. Szelenyi, P. Paldi-Haris, and S. Hollan, Changes in the cholinergic system of lymphocytes due to mitogenic stimulation, Immunol. Lett. 16:49 (1989).CrossRefGoogle Scholar
  20. 20.
    G. Freund, T.R. Brophy, and J.O. Scott, Membrane fluidity increases low-affinity muscarinic receptor binding in brain: changes with ageing, Exp. Geront. 21:37 (1986).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Judith Szelenyi
    • 1
  • Nguyen Thi Hu Ha
    • 1
  1. 1.National Institute of HaematologyBlood Transfusion and ImmunologyBudapestHungary

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