Neuroendocrine-Immune Interactions in the Gastrointestinal Tract

  • Hiroshi Nagura
  • Mitsuo Kimura
  • Mituru Kubota
  • Noriko Kimura
Part of the Hans Selye Symposia on Neuroendocrinology and Stress book series (HSSN, volume 3)


Gastrointestinal function is modulated by a complex series of neurohormonal interrelations. There is a great deal of evidence for the neurohormonal influence on various aspects of the immuno-inflammatory response of the gastrointestinal mucosa.1–4 Psychological stress, for example, can influence the symptoms of inflammation in such diseases as inflammatory bowel disease(IBD).5 The intestine contains highly specialized subdivisions of both the neuroendocrine and immune systems, and the mucosal surface is especially well designed to allow for interactions between nerves and the cells of the immune system.


Inflammatory Bowel Disease Lamina Propria Intestinal Mucosa Vasoactive Intestinal Peptide Immune Effector Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Hiroshi Nagura
    • 1
  • Mitsuo Kimura
    • 1
  • Mituru Kubota
    • 1
  • Noriko Kimura
    • 1
  1. 1.Department of PathologyTohoku University School of MedicineSendai 980Japan

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